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Submit ReviewPLX 647 dihydrochloride
Description: Potent dual Fms/KIT inhibitor
Chemical Name: 5-(1H-Pyrrolo[2,3-b]pyridin-3-ylmethyl)-N-[[4-(trifluoromethyl)phenyl]methyl]-2-pyridinamine dihydrochloride
Purity: ≥97% (HPLC)
Biological Activity for PLX 647 dihydrochloride
PLX 647 dihydrochloride is a potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.
Technical Data for PLX 647 dihydrochloride
| M. Wt | 455.3 |
| Formula | C21H17F3N4.2HCl |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 1779796-38-1 |
| PubChem ID | 78243730 |
| InChI Key | MVMKWLRKACAUTB-UHFFFAOYSA-N |
| Smiles | FC(C(C=C4)=CC=C4CNC(N=C3)=CC=C3CC2=CNC1=NC=CC=C12)(F)F.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PLX 647 dihydrochloride
References for PLX 647 dihydrochloride
References are publications that support the biological activity of the product.
Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID: 23493555
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