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Submit ReviewPomalidomide 4'-alkylC4-azide
Description: Cereblon ligand with alkyl linker and terminal azide for onward chemistry
Chemical Name: 4-[(4-Azidobutyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
Purity: ≥95% (HPLC)
Biological Activity for Pomalidomide 4'-alkylC4-azide
Pomalidomide 4'-alkylC4-azide is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC4 linker with terminal azide ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for Pomalidomide 4'-alkylC4-azide
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for Pomalidomide 4'-alkylC4-azide
| M. Wt | 370.37 |
| Formula | C17H18N6O4 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2758431-96-6 |
| PubChem ID | 150998891 |
| InChI Key | LTRNAKXZLMEDIP-UHFFFAOYSA-N |
| Smiles | O=C(N(C(C1=CC=C2)=O)C3CCC(NC3=O)=O)C1=C2NCCCCN=[N+]=[N-] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pomalidomide 4'-alkylC4-azide
References for Pomalidomide 4'-alkylC4-azide
References are publications that support the biological activity of the product.
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Keywords: Pomalidomide 4'-alkylC4-azide, Pomalidomide 4'-alkylC4-azide supplier, PROTAC, component, cereblon, E3, ubiquitin, ligase, AlkylC4, linker, conjugate, building, block, ligands, targeted, targeting, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7441, Tocris Bioscience
2 Citations for Pomalidomide 4'-alkylC4-azide
Citations are publications that use Tocris products. Selected citations for Pomalidomide 4'-alkylC4-azide include:
Keith W et al (2020) Pathological mutations in PNKP trigger defects in DNA single-strand break repair but not DNA double-strand break repair. Nucleic Acids Res 48 6672-6684 PMID: 32504494
Bo et al (2018) Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders. Nature 554 112-117 PMID: 29364875
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia