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Submit ReviewPomalidomide 4'-alkylC6-amine
Description: Cereblon ligand with alkyl linker and terminal amine for onward chemistry
Chemical Name: 4-[(6-Aminohexyl)amino]-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione hydrochloride
Purity: ≥95% (HPLC)
Biological Activity for Pomalidomide 4'-alkylC6-amine
Pomalidomide 4'-alkylC6-amine is a functionalized cereblon ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus an alkylC6 linker with terminal amine ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.
This product has been recently renamed. The previous name for this product was Pomalidomide - linker 4
Please contact us for SD files of our available Degrader Building Blocks.
PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Usage Guidelines for Pomalidomide 4'-alkylC6-amine
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for Pomalidomide 4'-alkylC6-amine
| M. Wt | 408.88 |
| Formula | C19H24N4O4.HCl |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 2375194-37-7 |
| PubChem ID | 139211246 |
| InChI Key | PBGMRXNTLPSDNR-UHFFFAOYSA-N |
| Smiles | Cl.O=C1NC(=O)C(N2C(=O)C=3C=CC=C(NCCCCCCN)C3C2=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pomalidomide 4'-alkylC6-amine
References for Pomalidomide 4'-alkylC6-amine
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Keywords: Pomalidomide 4'-alkylC6-amine, Pomalidomide 4'-alkylC6-amine supplier, PROTACs, components, cereblon, E3, ubiquitin, ligase, Alkyl, linker, conjugate, building, blocks, ligands, targeted, protein, degradation, TPD, Cereblon, Ligands, Plus, Linkers, 7923, Tocris Bioscience
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TPD and Induced Proximity Research Product GuideUpdated
This brochure highlights the tools and services available from Bio-Techne to support your Targeted Protein Degradation and Induced Proximity research, including:
- Active Degraders
- TAG Degradation Platform
- Degrader Building Blocks
- Assays for Protein Degradation
- Induced Proximity Tools
Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia