Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewPrasugrel
Description: Irreversible P2Y12 antagonist; antiplatelet and orally active
Alternative Names: LY640315,CS 747,Effient
Chemical Name: 2-[2-(Acetyloxy)-6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl]-1-cyclopropyl-2-(2-fluorophenyl)ethanone
Purity: ≥98% (HPLC)
Biological Activity for Prasugrel
Prasugrel is an irreversible P2Y12 antagonist; metabolised to active metabolite R-99224 (IC50 = 45 μM) irreversibly binds platelet P2Y12 receptors, inhibiting platelet activation. Antiplatelet and antithrombotic. Orally active and active in vivo. Note - inactive in vitro.
Compound Libraries for Prasugrel
Prasugrel is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Prasugrel
| M. Wt | 373.44 |
| Formula | C20H20FNO3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 150322-43-3 |
| PubChem ID | 6918456 |
| InChI Key | DTGLZDAWLRGWQN-UHFFFAOYSA-N |
| Smiles | CC(OC1=CC2=C(S1)CCN(C(C3=C(C=CC=C3)F)C(C4CC4)=O)C2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Prasugrel
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.34 | 100 |
Preparing Stock Solutions for Prasugrel
The following data is based on the product molecular weight 373.44. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.68 mL | 13.39 mL | 26.78 mL |
| 5 mM | 0.54 mL | 2.68 mL | 5.36 mL |
| 10 mM | 0.27 mL | 1.34 mL | 2.68 mL |
| 50 mM | 0.05 mL | 0.27 mL | 0.54 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for Prasugrel
References for Prasugrel
References are publications that support the biological activity of the product.
Sugidachi et al (2000) The in vivo pharmacological profile of CS-747, a novel antiplatelet agent with platelet ADP receptor antagonist properties. Br.J.Pharmacol. 129 1439 PMID: 10742300
Hashimoto (2007) The influence of P2Y12 receptor deficiency on the platelet inhibitory activities of pras. in a mouse model: evidence for specific inhibition of P2Y12 receptors by pras. Biochem.Pharmacol. 74 1003 PMID: 17681285
Huber et al (2009) Prasugrel. Nat.Rev.Drug Discov. 8 449 PMID: 19483707
If you know of a relevant reference for Prasugrel, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Prasugrel, Prasugrel supplier, LY640315, Prasugrel, P2Y12, purinergic, antagonists, receptors, purinoceptors, adenosine, CS_747, CS747, Effient, Efient, antiplatelet, atherosclerosis, antithromboembolic, orally, active, in, vivo, antagonises, inhibitors, inhibits, CS, 747, Purinergic, P2Y, Receptors, 6317, Tocris Bioscience
Citations for Prasugrel
Citations are publications that use Tocris products.
Currently there are no citations for Prasugrel. Do you know of a great paper that uses Prasugrel from Tocris? Please let us know.
Reviews for Prasugrel
There are currently no reviews for this product. Be the first to review Prasugrel and earn rewards!
Have you used Prasugrel?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.