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Submit ReviewPristimerin
Description: Potent, reversible MAGL inhibitor
Chemical Name: (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid methyl ester
Purity: ≥99% (HPLC)
Biological Activity for Pristimerin
Pristimerin is a potent and reversible inhibitor of monoacylglycerol lipase (MGL) (IC50 = 93 nM). Also suppresses NF-κB activation via inhibition of proteasome chymotrypsin-like activity and IKKαβ. Displays antitumor, anti-inflammatory and antimicrobial activities.
Technical Data for Pristimerin
| M. Wt | 464.64 |
| Formula | C30H40O4 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1258-84-0 |
| PubChem ID | 159516 |
| InChI Key | JFACETXYABVHFD-WXPPGMDDSA-N |
| Smiles | O=C2C(O)=C(C)C1=CC=C([C@](CC[C@]5(C)[C@]([H])4C[C@](C)([C@](OC)=O)CC5)(C)[C@@]4(C)CC3)[C@]3(C)C1=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Pristimerin
References for Pristimerin
References are publications that support the biological activity of the product.
Byun et al (2009) Reactive oxygen species-dependent activation of Bax and Poly(ADP)-ribose) polymerase-1 is requried for mitochondrial cell death induced by triterpenoid Pristimerin in human cervical cancer cells. Mol.Pharmacol. 76 734 PMID: 19574249
Tiedemann et al (2009) Identification of a potent natural triterpenoid inhibitor of proteosome chymotrypsin-like activity and NF-κB with antimyeloma activity in vitro and in vivo. Blood 113 4027 PMID: 19096011
King et al (2009) Discovery of potent and reversible monoacylglycerol lipase inhibitors. Chem.Biol. 16 1045 PMID: 19875078
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Keywords: Pristimerin, Pristimerin supplier, MAGL, MGL, monoacylglycerol, lipase, inhibitors, lipases, NF-kB, NF-kappaB, NF-κB, inhibits, suppresses, activation, nuclear, factor, kappa, B, transcription, factors, NF-kB/IkB, 3731, Tocris Bioscience
1 Citation for Pristimerin
Citations are publications that use Tocris products. Selected citations for Pristimerin include:
El-Agamy et al (2018) Pristimerin as a Novel Hepatoprotective Agent Against Experimental Autoimmune Hepatitis. Front Pharmacol 9 292 PMID: 29643811
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