Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewProsaptide TX14(A)
Description: Potent GPR37 and GPR37L1 agonist
Purity: ≥95% (HPLC)
Biological Activity for Prosaptide TX14(A)
Prosaptide TX14(A) is a potent GPR37L1 and GPR37 agonist (EC50 values are 5 and 7 nM, respectively). Stimulates signaling through pertussis toxin-sensitive G proteins. Stimulates ERK phosphorylation. Protects against cellular stress. Promotes myelin lipid synthesis and prolongs cell survival in both Schwann cells and oligodendrocytes; neuroprotective and glioprotective.
Technical Data for Prosaptide TX14(A)
| M. Wt | 1579.72 |
| Formula | C69H110N16O26 |
| Sequence |
TALIDNNATEEILY (Modification: Ala-2 = D-Ala) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 196391-82-9 |
| PubChem ID | 16197909 |
| InChI Key | SMUKRAODILXPSW-SRWCCNGVSA-N |
| Smiles | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Prosaptide TX14(A)
| Solubility | Soluble to 2 mg/ml in water |
Product Datasheets for Prosaptide TX14(A)
References for Prosaptide TX14(A)
References are publications that support the biological activity of the product.
Hiraiwa et al (1997) Cell death prevention, mitogen-activated protein kinase stimulation, and increased sulfatide concentrations in Schwann cells and oligodendrocytes by prosaposin and prosaptides. Proc.Natl.Acad.Sci.USA. 94 4778 PMID: 9114068
Meyer et al (2013) GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc.Natl.Acad.Sci.USA. 110 9529 PMID: 23690594
If you know of a relevant reference for Prosaptide TX14(A), please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: Prosaptide TX14(A), Prosaptide TX14(A) supplier, Potent, GPR37, GPR37L1, orphan, receptors, agonists, PTX-sensitive, neuroprotective, glioprotective, Orphan, 7-TM, Receptors, 5151, Tocris Bioscience
Citations for Prosaptide TX14(A)
Citations are publications that use Tocris products.
Currently there are no citations for Prosaptide TX14(A). Do you know of a great paper that uses Prosaptide TX14(A) from Tocris? Please let us know.
Reviews for Prosaptide TX14(A)
There are currently no reviews for this product. Be the first to review Prosaptide TX14(A) and earn rewards!
Have you used Prosaptide TX14(A)?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image