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Submit ReviewProstaglandin F2α
Description: Naturally-occurring prostanoid; potent vasoconstrictor
Chemical Name: 9α,11α,15S-Trihydroxy-prosta-5Z,13E-dien-1-oic acid tris(hydroxymethyl)aminomethane salt
Purity: ≥98% (HPLC)
Biological Activity for Prostaglandin F2α
Prostaglandin F2α is a prostaglandin E2 and F2α receptor agonist. Naturally-occurring prostaglandin and potent vasoconstrictor. Induces cardiomyocyte hypertrophy in vitro. Exhibits luteolytic activity.
Technical Data for Prostaglandin F2α
| M. Wt | 475.62 |
| Formula | C20H34O5.C4H11NO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 38562-01-5 |
| PubChem ID | 5282415 |
| InChI Key | IYGXEHDCSOYNKY-RZHHZEQLSA-N |
| Smiles | O[C@@H]1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1.NC(CO)(CO)CO |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Prostaglandin F2α
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.56 | 100 | |
| ethanol | 47.56 | 100 |
Preparing Stock Solutions for Prostaglandin F2α
The following data is based on the product molecular weight 475.62. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.1 mL | 10.51 mL | 21.03 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.21 mL |
| 10 mM | 0.21 mL | 1.05 mL | 2.1 mL |
| 50 mM | 0.04 mL | 0.21 mL | 0.42 mL |
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Product Datasheets for Prostaglandin F2α
References for Prostaglandin F2α
References are publications that support the biological activity of the product.
Samuelsson et al (1978) Prostaglandins and throboxanes. Annu.Rev.Biochem. 47 997 PMID: 209733
Girsh and Dekel (2002) Involvement of endothelin-1 and its receptors in PGF2α-induced luteolysis in the rat. Mol.Reprod.Dev. 63 71 PMID: 12211063
Lai et al (1996) Prostaglandin F2 alpha induces cardiac myocyte hypertrophy in vitro and cardiac growth in vivo. Am.J.Physiol. 271 2197
If you know of a relevant reference for Prostaglandin F2α, please let us know.
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