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PSB 11 hydrochloride

Cat. No. 2012 Submit a Review Datasheet / COA / SDS

Discontinued Product

2012 has been discontinued.

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Description: Potent, selective hA3 receptor antagonist/inverse agonist
Chemical Name: (8R)-8-Ethyl-1,4,7,8-tetrahydro-4-5H-imidazo[2,1-i]purin-5-one hydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for PSB 11 hydrochloride

PSB 11 hydrochloride is a potent and selective antagonist for the human adenosine A3 receptor, with low affinity for the rat A3 receptor (Ki values are 2.3 and > 10000 nM respectively). Displays > 1000-fold selectivity over human A1 and A2A receptors (Ki values are 4.1 and 3.3 μM respectively) and > 180-fold selectivity over rat A1, rat A2A and mouse A2B receptors. Acts as an inverse agonist in the [35S]GTPγS binding assay in hA3-CHO cells (IC50 = 36 nM).

Technical Data for PSB 11 hydrochloride

M. Wt 331.8
Formula C16H17N5O.HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 453591-58-7
PubChem ID 16759152
InChI Key JAUSHKIWPLHBCN-RFVHGSKJSA-N
Smiles Cl[H].CC[C@@H]1CN2C(=N1)C1=C(N=C(N1)C1=CC=CC=C1)N(C)C2=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for PSB 11 hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for PSB 11 hydrochloride

References are publications that support the biological activity of the product.

Muller et al (2002) Imidazo[2,1-i]purin-5-ones and related tricyclic water-soluble purine derivatives: potent A2A- and A3-adenosine receptor antagonists. J.Med.Chem. 45 3440 PMID: 12139454

Muller (2003) Medicinal chemistry of adenosine A3 receptor ligands. Curr.Top.Med.Chem. 3 445 PMID: 12570761

Ozola et al (2003) 2-Phenylimidazo[2,1-i]purin-5-ones: structure-activity relationships and characterization of potent and selective inverse agonists at human A3 adenosine receptors. Bioorg.Med.Chem. 11 347 PMID: 12517430

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Citations for PSB 11 hydrochloride

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