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Submit ReviewPSB CB5
Description: Selective GPR18 antagonist
Chemical Name: (2Z)-2[[3-[(4-Chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one
Purity: ≥98% (HPLC)
Biological Activity for PSB CB5
PSB CB5 is a selective GPR18 antagonist (IC50 = 0.279 μM). Exhibits >36-fold selectivity versus CB1 and GPR55 and 14-fold selectivity versus CB2 receptors. Inhibits N-Arachidonylglycine (Cat. No. 1445) induced acrosomal exocytosis in human spermatozoa.
Compound Libraries for PSB CB5
PSB CB5 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for PSB CB5
| M. Wt | 384.88 |
| Formula | C20H17ClN2O2S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1627710-30-8 |
| PubChem ID | 85469571 |
| InChI Key | XJBQRMOGMULGPP-PDGQHHTCSA-N |
| Smiles | O=C(N1C(SCCC1)=N/2)C2=C\C3=CC(OCC4=CC=C(Cl)C=C4)=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSB CB5
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.7 | 20 |
Preparing Stock Solutions for PSB CB5
The following data is based on the product molecular weight 384.88. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.99 mL | 64.96 mL | 129.91 mL |
| 1 mM | 2.6 mL | 12.99 mL | 25.98 mL |
| 2 mM | 1.3 mL | 6.5 mL | 12.99 mL |
| 10 mM | 0.26 mL | 1.3 mL | 2.6 mL |
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Product Datasheets for PSB CB5
References for PSB CB5
References are publications that support the biological activity of the product.
Rempel et al (2014) Bicyclic imidazole-4-one derivatives: a new class of antagonists for the orphan G protein-coupled receptors GPR18 and GPR55. Med.Chem.Comm. 5 632
Flegel et al (2016) Characterization of non-olfactory GPCRs in human sperm with a focus on GPR18. Sci.Rep. 6 32255 PMID: 27572937
If you know of a relevant reference for PSB CB5, please let us know.
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Keywords: PSB CB5, PSB CB5 supplier, PSBCB5, GPR18, selective, antagonist, Other, Cannabinoids, 6372, Tocris Bioscience
1 Citation for PSB CB5
Citations are publications that use Tocris products. Selected citations for PSB CB5 include:
Michael N et al (2023) N-arachidonylglycine is a caloric state-dependent circulating metabolite which regulates human CD4+T cell responsiveness. iScience 26 106578 PMID: 37128607
Do you know of a great paper that uses PSB CB5 from Tocris? Please let us know.
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Literature in this Area
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.