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Submit ReviewPSEM 308 hydrochloride
Description: PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 chimeric ion channel agonist
Chemical Name: 5-Methyl-5,8,9,10,11a,12-hexahydro-4H-8,11-ethanopyrido[3',2':3,4]diazepino[6,7,1-hi]indole hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PSEM 308 hydrochloride
PSEM 308 hydrochloride is a PSAM (pharmacologically selective actuator module) agonist. Activates PSAML141F-GlyR chimeric ion channels. Inhibits activity of neurons expressing PSAML141F-GlyR in vivo and activates locus coeruleus noradrenergic neurons expressing PSAML141F,Y115F-5-HT3 ion channels.
Recommended concentration for use in mice is 5 mg/kg or lower.
Plasmid vectors for the transfection of cells with PSAML141F-GlyR and PSAML141F,Y115F-5-HT3 are available from Addgene.
Licensing Information
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
For scientific research use only. This product may not be used to research, develop, make, use, offer to sell, sell, or import any products for human therapeutic uses.
Technical Data for PSEM 308 hydrochloride
| M. Wt | 303.83 |
| Formula | C17H21N3.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| PubChem ID | 134812838 |
| InChI Key | VMTPPUMVLGEJNP-UHFFFAOYSA-N |
| Smiles | CC1CC2=CC=CC3=C2N1N=C4C(C3)[N@@]5CC[C@H]4CC5.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for PSEM 308 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 6.08 | 20 | |
| ethanol | 6.08 | 20 with gentle warming |
Preparing Stock Solutions for PSEM 308 hydrochloride
The following data is based on the product molecular weight 303.83. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 16.46 mL | 82.28 mL | 164.57 mL |
| 1 mM | 3.29 mL | 16.46 mL | 32.91 mL |
| 2 mM | 1.65 mL | 8.23 mL | 16.46 mL |
| 10 mM | 0.33 mL | 1.65 mL | 3.29 mL |
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Product Datasheets for PSEM 308 hydrochloride
References for PSEM 308 hydrochloride
References are publications that support the biological activity of the product.
Lovett-Barron et al (2012) Regulation of neuronal input transformations by tunable dendritic inhibition. Nat.Neurosci. 15 423 PMID: 22246433
Satoh et al (2016) Context-dependent gait choice elicited by EphA4 mutation in Lbx1 spinal interneurons. Neuron 89 1046 PMID: 26924434
Atasoy et al (2012) Deconstruction of a neural circuit for hunger. Nature 488 172 PMID: 22801496
Hirschberg et al (2017) Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. Elife 6 e29808 PMID: 29027903
If you know of a relevant reference for PSEM 308 hydrochloride, please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.