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Submit ReviewPSN 375963 hydrochloride
Description: GPR119 receptor agonist
Chemical Name: 4-[5-(4-Butylcyclohexyl)-1,2,4-oxadiazol-3-yl]-pyridine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for PSN 375963 hydrochloride
GPR119 receptor agonist (EC50 values are 8.4 and 7.9 μM at human and mouse receptors respectively). Displays similar potency to the endogenous ligand oleylethanolamide (OEA) (Cat. No. 1484).
Technical Data for PSN 375963 hydrochloride
| M. Wt | 321.84 |
| Formula | C17H23N3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1781834-82-9 |
| PubChem ID | 56972228 |
| InChI Key | ONDLSENXTCSHGC-UHFFFAOYSA-N |
| Smiles | CCCCC(CC3)CCC3C1=NC(C2=CC=NC=C2)=NO1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for PSN 375963 hydrochloride
References for PSN 375963 hydrochloride
References are publications that support the biological activity of the product.
Overton et al (2006) Deorphanization of a G protein-coupled receptor for oleoylethanolamide and its use in the discovery of small-molecule hypophagic agents. Cell Metab. 3 167 PMID: 16517404
Ning et al (2008) Endogenous and synthetic agonists of GPR119 differ in signalling pathways and their effects on Ins secretion in MIN6c4 Insoma cells. Br.J.Pharmacol. 155 1056 PMID: 18724386
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Keywords: PSN 375963 hydrochloride, PSN 375963 hydrochloride supplier, GPR119, receptors, agonists, PSN375963, hydrochloride, 3353, Tocris Bioscience
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