Purvalanol A

Cat. No. 1580 8 Citations Submit a Review Datasheet / COA / SDS

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Description: Cdk inhibitor; potently inhibits cdk1, cdk2 and cdk5

Alternative Names: NG 60

Chemical Name: (2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanol

Purity: ≥98% (HPLC)

Datasheet

Citations (8)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Purvalanol A

Purvalanol A is a cyclin-dependent kinase (cdk) inhibitor (reported IC₅₀ values are 4, 4 - 70, 75 - 240 and 100 nM for cdk1, cdk2, cdk5 and cdk 7, respectively). Reversibly arrests synchronised cells in G1 and G2, and inhibits cell proliferation and cell death.

Licensing Information

Sold under license from the Regents of the University of California

Compound Libraries for Purvalanol A

Purvalanol A is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Purvalanol A

M. Wt	388.9
Formula	C₁₉H₂₅ClN₆O
Storage	Store at +4°C
Purity	≥98% (HPLC)
CAS Number	212844-53-6
PubChem ID	456214
InChI Key	PMXCMJLOPOFPBT-HNNXBMFYSA-N
Smiles	ClC1=CC=CC(NC2=C3C(N(C(C)C)C=N3)=NC(N[C@H]([C@@H](C)C)CO)=N2)=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Purvalanol A

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	ethanol	19.45	50
	DMSO	38.89	100

Preparing Stock Solutions for Purvalanol A

The following data is based on the product molecular weight 388.9. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.57 mL	12.86 mL	25.71 mL
5 mM	0.51 mL	2.57 mL	5.14 mL
10 mM	0.26 mL	1.29 mL	2.57 mL
50 mM	0.05 mL	0.26 mL	0.51 mL

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Product Datasheets for Purvalanol A

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Purvalanol A

References are publications that support the biological activity of the product.

Bain et al (2003) The specificities of protein kinase inhibitors: an update. Biochem.J. 371 199 PMID: 12534346

Gray et al (1998) Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science 281 533 PMID: 9677190

Gray et al (1999) ATP-site directed inhibitors of cyclin-dependent kinases. Curr.Med.Chem. 6 859 PMID: 10495356

Villerbu et al (2002) Cellular effects of purvalanol A: a specific inhibitor of cyclin-dependent kinase activities. Int.J.Cancer 97 761 PMID: 11857351

Jorda et al (2018) How selective are pharmacological inhibitors of cell-cycle-regulating cyclin-dependent kinases? J.Med.Chem. 61 9105 PMID: 30234987

If you know of a relevant reference for Purvalanol A, please let us know.

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Keywords: Purvalanol A, Purvalanol A supplier, Cyclin-dependent, protein, kinases, inhibitors, inhibits, Cdk, PurvalanolA, NG60, NG, 60, Kinase, Non-selective, CDKs, 1580, Tocris Bioscience