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Submit ReviewQO 58
Description: Kv7 channel opener
Chemical Name: 5-(2,6-Dichloro-5-fluoro-3-pyridinyl)-3-phenyl-2-(trifluoromethyl)-pyrazolo[1,5-a]pyrimidin-7(4H)-one
Purity: ≥98% (HPLC)
Biological Activity for QO 58
QO 58 is a Kv7 channel opener (EC50 values are 0.6, 1.0, 5.2 and 7.0 μM for Kv7.4, Kv7.2, Kv7.3/7.5 and Kv7.1, respectively). Increases the pain threshold of neuropathic pain in a sciatic nerve CCI in vivo model.
Compound Libraries for QO 58
QO 58 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for QO 58
| M. Wt | 443.18 |
| Formula | C18H8Cl2F4N4O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1259536-62-3 |
| PubChem ID | 51351551 |
| InChI Key | ZOLHKPWSDFSDKA-UHFFFAOYSA-N |
| Smiles | O=C1C=C(C4=CC(F)=C(Cl)N=C4Cl)NC2=C(C3=CC=CC=C3)C(C(F)(F)F)=NN12 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for QO 58
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.16 | 50 |
Preparing Stock Solutions for QO 58
The following data is based on the product molecular weight 443.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.51 mL | 22.56 mL | 45.13 mL |
| 2.5 mM | 0.9 mL | 4.51 mL | 9.03 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.51 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.9 mL |
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Product Datasheets for QO 58
References for QO 58
References are publications that support the biological activity of the product.
Zhang et al (2013) Modulation of Kv7 potassium channels by a novel opener pyrazolo[1,5-a]pyrimidin-7(4H)-one compound QO-58. Br.J.Pharmacol. 168 1030 PMID: 23013484
Qi et al (2011) Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators. Eur.J.Med.Chem. 46 934 PMID: 21296466
If you know of a relevant reference for QO 58, please let us know.
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Keywords: QO 58, QO 58 supplier, Kv7, openers, K+, channel, activators, voltage, gated, potassium, channels, neuropathic, pain, Voltage-Gated, Potassium, Channels, 5083, Tocris Bioscience
Citations for QO 58
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Currently there are no citations for QO 58. Do you know of a great paper that uses QO 58 from Tocris? Please let us know.
Reviews for QO 58
Average Rating: 5 (Based on 1 Review.)
Have you used QO 58?
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QO 58 used for to understand channel opening properties.
By
Anonymous on 10/13/2018
Assay Type: In Vitro
Species: Human
Our University lab used this product for years to study channel opening properties. Worked great on lab conditions and shows different rates on channel opening on different cell lines. Great product, would buy again and recommend.
