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Submit ReviewQuetiapine hemifumarate
Description: 5-HT2 antagonist; also D2 antagonist; atypical antipsychotic
Alternative Names: ICI 204,636
Chemical Name: 2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate
Purity: ≥99% (HPLC)
Biological Activity for Quetiapine hemifumarate
Quetiapine hemifumarate is an atypical antipsychotic. Displays antagonist activity at serotonin (5-HT2) and dopamine (D2) receptors (IC50 values are 148 and 329 nM respectively). Lacks affinity at either D1 or muscarinic receptors.
Compound Libraries for Quetiapine hemifumarate
Quetiapine hemifumarate is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Quetiapine hemifumarate
| M. Wt | 441.54 |
| Formula | C21H25N3O2S.0.5C4H4O4 |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 111974-72-2 |
| PubChem ID | 5281025 |
| InChI Key | ZTHJULTYCAQOIJ-WXXKFALUSA-N |
| Smiles | OCCOCCN(CC4)CCN4C2=NC1=CC=CC=C1SC3=C2C=CC=C3.O=C(/C=C/C(O)=O)O.OCCOCCN(CC8)CCN8C6=NC5=CC=CC=C5SC7=C6C=CC=C7 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Quetiapine hemifumarate
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 22.08 | 50 |
Preparing Stock Solutions for Quetiapine hemifumarate
The following data is based on the product molecular weight 441.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 4.53 mL | 22.65 mL | 45.3 mL |
| 2.5 mM | 0.91 mL | 4.53 mL | 9.06 mL |
| 5 mM | 0.45 mL | 2.26 mL | 4.53 mL |
| 25 mM | 0.09 mL | 0.45 mL | 0.91 mL |
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Product Datasheets for Quetiapine hemifumarate
References for Quetiapine hemifumarate
References are publications that support the biological activity of the product.
Saller and Salama (1993) Seroquel: biochemical profile of a potential atypical antipsychotic. Psychopharmacology (Berl.) 112 285 PMID: 7871032
Ellenbroek et al (1996) Activity of "seroquel" (ICI 204,636) in animal models for atypical properties of antipsychotics: a comparison with cloz. Neuropsychopharmacology 15 406 PMID: 8887995
If you know of a relevant reference for Quetiapine hemifumarate, please let us know.
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Keywords: Quetiapine hemifumarate, Quetiapine hemifumarate supplier, antipsychotics, serotonin, 5-HT, 5-HT2, dopamine, D2, receptors, ICI204636, antagonists, ICI, 204,636, Non-selective, Receptors, 4735, Tocris Bioscience
Citations for Quetiapine hemifumarate
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Currently there are no citations for Quetiapine hemifumarate. Do you know of a great paper that uses Quetiapine hemifumarate from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.