Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewR 715
Description: Potent and selective B1 antagonist
Purity: ≥95% (HPLC)
Biological Activity for R 715
R 715 is a potent and selective bradykinin B1 receptor antagonist (pA2 = 8.49). Displays no activity at B2 receptors. Reduces mechanical hypernociception in a mouse model of neuropathic pain. Metabolically stable.
Technical Data for R 715
| M. Wt | 1140.35 |
| Formula | C57H81N13O12 |
| Sequence |
KRPPGFSXI (Modifications: Lys-1 = N-terminal Ac, X = DβNal) |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 185052-09-9 |
| PubChem ID | 5311397 |
| InChI Key | DOSXOGUJJBDRGQ-VUBDHFCFSA-N |
| Smiles | CC[C@H](C)[C@H](NC(=O)[C@@H](CC1=CC2=CC=CC=C2C=C1)NC(=O)[C@H](CO)NC(=O)[C@H](CC1=CC=CC=C1)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(C)=O)C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for R 715
| Solubility | Soluble to 5 mg/ml in water |
Product Datasheets for R 715
References for R 715
References are publications that support the biological activity of the product.
Gobeil et al (1996) Structure-activity studies of B1 receptor-related peptides. Hypertension. 28 833 PMID: 8901831
Quintao et al (2008) Neuropathic pain-like behavior after brachial plexus avulsion in mice: the relevance of kinin B1 and B2 receptors. J.Neurosci. 28 2856 PMID: 18337416
Abdouh et al (2008) Retinal plasma extravasation in streptozotocin-diabetic rats mediated by kinin B1 and B2 receptors. Br.J.Pharmacol. 154 136 PMID: 18311190
If you know of a relevant reference for R 715, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: R 715, R 715 supplier, Potent, selective, B1, antagonists, Receptors, Bradykinin, R715, 3407, Tocris Bioscience
6 Citations for R 715
Citations are publications that use Tocris products. Selected citations for R 715 include:
Brailoiu (2017) Modulation of cardiac vagal tone by bradykinin acting on nucleus ambiguus. Neuroscience 365 23 PMID: 28951324
Pinheiro et al (2013) Bradykinin-induced Ca2+ signaling in human subcutaneous fibroblasts involves ATP release via hemichannels leading to P2Y12 receptors activation. Cell Commun Signal 11 70 PMID: 24047499
Falsetta et al (2016) A role for bradykinin signaling in chronic vulvar pain. The Journal of Pain PMID: 27544818
Xu et al (2014) Nicotine exaggerates LPS-induced airway hyperreactivity via JNK-mediated up-regulation of Toll-like receptor 4. Am J Respir Cell Mol Biol 51 370 PMID: 24669857
Albert-Weissenberger et al (2012) Blocking of bradykinin receptor B1 protects from focal closed head injury in mice by reducing axonal damage and astroglia activation. EMBO Mol Med 32 1747 PMID: 22569191
Kawaguchi et al (2015) Functional expression of bradykinin B1 and B2 receptors in neonatal rat trigeminal ganglion neurons. J Cereb Blood Flow Metab 9 229 PMID: 26124706
Do you know of a great paper that uses R 715 from Tocris? Please let us know.
Reviews for R 715
Average Rating: 5 (Based on 1 Review.)
Have you used R 715?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Filter by:
works good.
By
Anonymous on 05/13/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: neurons
B1 receptor antagonist R715, 2 µM
treat 20 min
