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Description: Dopamine uptake inhibitor
Alternative Names: armodafinil
Chemical Name: (-)-2R-[(Diphenylmethyl)sulfinyl]acetamide
Purity: ≥98% (HPLC)
Biological Activity for (R)-Modafinil
(R)-Modafinil is a dopamine uptake inhibitor (IC50 = 4 μM). Increases extracellular dopamine (DA) levels in the nucleus accumbens and substitutes for cocaine in discrimination tests in mice.
Technical Data for (R)-Modafinil
| M. Wt | 273.35 |
| Formula | C15H15NO2S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 112111-43-0 |
| PubChem ID | 9690109 |
| InChI Key | YFGHCGITMMYXAQ-LJQANCHMSA-N |
| Smiles | O=[S@](CC(N)=O)C(C1=CC=CC=C1)C2=CC=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for (R)-Modafinil
References for (R)-Modafinil
References are publications that support the biological activity of the product.
Loland et al (2012) R-modafinil (armodafinil): a unique DA uptake inhibitor and potential medication for psychostimulant abuse. Biol.Psychiatry 72 405 PMID: 22537794
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Keywords: (R)-Modafinil, (R)-Modafinil supplier, dopamine, transporters, reuptake, inhibitors, inhibits, DAT, R-enantiomer, cocaine, discrimination, armodafinil, Dopamine, Transporters, 6131, Tocris Bioscience
Citations for (R)-Modafinil
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Currently there are no citations for (R)-Modafinil.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Dopamine Receptors Scientific Review
Written by Phillip Strange and revised by Kim Neve in 2013, this review summarizes the history of the dopamine receptors and provides an overview of individual receptor subtype properties, their distribution and identifies ligands which act at each receptor subtype. Compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.