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Description: Potent negative modulator of KCa2.3 and KCa3.1 channels
Chemical Name: 1,3-Phenylenebis(methylene)bis(3-fluoro-4-hydroxybenzoate)
Purity: ≥98% (HPLC)
Biological Activity for RA 2
RA 2 is a potent negative modulator of calcium-activated potassium channels KCa2.3 and KCa3.1 (IC50 values are 2 and 17 nM, respectively), which displays >55-fold selectively for KCa2 and KCa3.1 over other KCa, Kv and Kir channels. In ex vivo porcine coronary endothelium, RA 2 inhibits SKA 31 (Cat. No. 3670)-induced KCa2/KCa3.1 currents and TRAM 34 (Cat. No. 2946)-insensitive KCa2 currents. Reduces heart rate in mice in a KCa3.1-dependent manner.
Compound Libraries for RA 2
RA 2 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for RA 2
| M. Wt | 414.36 |
| Formula | C22H16F2O6 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1867107-62-7 |
| InChI Key | XOZKRECPKXTNAK-UHFFFAOYSA-N |
| Smiles | OC1=C(C=C(C(OCC2=CC(COC(C3=CC(F)=C(C=C3)O)=O)=CC=C2)=O)C=C1)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RA 2
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 41.44 | 100 | |
| ethanol | 41.44 | 100 |
Preparing Stock Solutions for RA 2
The following data is based on the product molecular weight 414.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.41 mL | 12.07 mL | 24.13 mL |
| 5 mM | 0.48 mL | 2.41 mL | 4.83 mL |
| 10 mM | 0.24 mL | 1.21 mL | 2.41 mL |
| 50 mM | 0.05 mL | 0.24 mL | 0.48 mL |
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Product Datasheets for RA 2
References for RA 2
References are publications that support the biological activity of the product.
Olivan-Viguera et al (2015) A novel pan-negative-gating modulator of KCa2/3 channels, fluoro-di-benzoate, RA-2, inhibits endothelium-derived hyperpolarization-type relaxation in coronary artery and produces bradycardia in vivo. Mol.Pharmacol. 338 PMID: 25468883
Olivan-Viguera et al (2016) Vascular reactivity profile of novel KCa3.1-selective positive-gating modulators in the coronary vascular bed. Basic Clin.Pharmacol.Toxicol. 119 184 PMID: 26821335
If you know of a relevant reference for RA 2, please let us know.
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Keywords: RA 2, RA 2 supplier, RA-2, negative, gating, modulator, KCa, 3.1, 2.3, Ik, SK, calcium, sensitive, activated, potassium, channels, Ca2+-Activated, Potassium, Channels, 7129, Tocris Bioscience
Citations for RA 2
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