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Description: Potent and selective postitive allosteric modulator of GABAB receptors
Chemical Name: 5,7-Bis(1,1-dimethylethyl)-3-hydroxy-3(trifluoromethyl)-2(3H)-benzofuranone
Purity: ≥98% (HPLC)
Biological Activity for rac BHFF
rac BHFF is a potent and selective GABAB receptor positive allosteric modulator that increases the potency and efficacy of GABA ( > 15-fold and > 149% respectively). Exhibits anxiolytic activity in vivo and is orally active.
Compound Libraries for rac BHFF
rac BHFF is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for rac BHFF
| M. Wt | 330.34 |
| Formula | C17H21F3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 123557-91-5 |
| PubChem ID | 4332683 |
| InChI Key | RVNOANDLZIIFHB-UHFFFAOYSA-N |
| Smiles | CC(C)(C)C1=C2C(C(O)(C(F)(F)F)C(O2)=O)=CC(C(C)(C)C)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for rac BHFF
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.03 | 100 | |
| ethanol | 33.03 | 100 |
Preparing Stock Solutions for rac BHFF
The following data is based on the product molecular weight 330.34. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.03 mL | 15.14 mL | 30.27 mL |
| 5 mM | 0.61 mL | 3.03 mL | 6.05 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.03 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.61 mL |
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Product Datasheets for rac BHFF
References for rac BHFF
References are publications that support the biological activity of the product.
Malherbe et al (2008) Characterization of (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one as a positive allosteric modulator of GABAB receptors. Br.J.Pharmacol. 154 797 PMID: 18536733
Koek et al (2013) Discriminative stimulus effects of the GABAB receptor-positive modulator rac-BHFF: comparison with GABAB receptor agonists and drugs of abuse. J.Pharmacol.Exp.Ther. 344 553 PMID: 23275067
If you know of a relevant reference for rac BHFF, please let us know.
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Keywords: rac BHFF, rac BHFF supplier, Potent, selective, GABAB, positive, allosteric, modulators, Receptors, 3313, Tocris Bioscience
1 Citation for rac BHFF
Citations are publications that use Tocris products. Selected citations for rac BHFF include:
Zhang et al (2015) GABAB receptor upregulates fragile X mental retardation protein expression in neurons. Clin Exp Dermatol 5 10468 PMID: 26020477
Do you know of a great paper that uses rac BHFF from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
GABA Receptors Scientific Review
Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
Addiction Poster
The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.