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Submit ReviewRalfinamide mesylate
Discontinued Product
4029 has been discontinued.
View all Voltage-gated Sodium (Na<sub>V</sub>) Channels products.
Description: Na+ channel blocker
Chemical Name: (2S)-2-[[[4-[(2-Fluorophenyl)methoxy]phenyl]methyl]amino]-propanamide methanesulfonate
Purity: ≥99% (HPLC)
Biological Activity for Ralfinamide mesylate
Ralfinamide mesylate is a sodium channel blocker. Suppresses tetrodotoxin (TTX)-resistant Na+ currents approximately twice as selectively as TTX-sensitive currents. Antinociceptive; displays analgesic effects in animal models of inflammatory and neuropathic pain.
Technical Data for Ralfinamide mesylate
| M. Wt | 398.45 |
| Formula | C17H19FN2O2.CH3SO3H |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 202825-45-4 |
| PubChem ID | 23661379 |
| InChI Key | CHQVNINIGBRKGZ-YDALLXLXSA-N |
| Smiles | FC(C=CC=C2)=C2COC1=CC=C(CN[C@@H](C)C(N)=O)C=C1.CS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ralfinamide mesylate
References for Ralfinamide mesylate
References are publications that support the biological activity of the product.
Veneroni et al (2003) Anti-allodynic effect of NW-1029, a novel Na+ channel blocker, in experimental animal models of inflammatory and neuropathic pain. Pain 102 17 PMID: 12620593
Yamane et al (2007) Effects of ralfinamide, a Na+ channel blocker, on firing properties of nociceptive dorsal root ganglion neurons of adult rats. Exp.Neurol. 208 63 PMID: 17707373
Zhang et al (2008) Ralfinamide administered orally before hindpaw neurectomy or postoperatively provided long-lasting suppression of spontaneous neuropathic pain-related behavior in the rat. Pain 139 293 PMID: 18583049
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Keywords: Ralfinamide mesylate, Ralfinamide mesylate supplier, Ralfinamide, sodium, Na+, blockers, channels, NaV, tetrodotoxin, TTXr, TTXs, TTX, Voltage-gated, Sodium, Channels, 4029, Tocris Bioscience
Citations for Ralfinamide mesylate
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Currently there are no citations for Ralfinamide mesylate.
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