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Submit ReviewRC 160
Description: sst analog
Alternative Names: Vapreotide
Biological Activity for RC 160
RC 160 is a cyclic octapeptide somatostatin analog (Ki values are 0.7, 5.4, 30.9, 45 and > 1000 nM for sst5, sst2, sst3, sst4 and sst1 receptors respectively). More metabolically stable than somatostatin (Cat. No. 1157). Inhibits growth hormone release in vivo.
Technical Data for RC 160
| M. Wt | 1131.37 |
| Formula | C57H70N12O9S2 |
| Sequence |
FCYWKVCW (Modifications: Phe-1 = D-Phe, Trp-4 = D-Trp, Trp-8 = C-terminal amide, Disulfide bridge between 2 - 7) |
| Storage | Desiccate at -20°C |
| CAS Number | 103222-11-3 |
| PubChem ID | 6918026 |
| InChI Key | SWXOGPJRIDTIRL-DOUNNPEJSA-N |
| Smiles | [H]N[C@H](CC1=CC=CC=C1)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](CC2=CNC3=C2C=CC=C3)NC(=O)[C@H](CC2=CC=C(O)C=C2)NC1=O)C(C)C)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RC 160
References for RC 160
References are publications that support the biological activity of the product.
Karashima et al (1987) Effects of highly potent octapeptide analogs of somatostatin on GH, Ins and glucagon release. Life Sci. 41 1011 PMID: 2886886
Patel and Srikant (1994) Subtype selectivity of peptide analogs for all five coned human somatostatin receptors (hsstr 1-5). Endocrinology 135 2814 PMID: 7988476
Lahlou et al (2003) sst2 Somatostatin receptor inhibits cell proliferation through Ras- Rap1-, and B-raf-dependent ERK2 activation. J.Biol.Chem. 278 39356 PMID: 12878607
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Keywords: RC 160, RC 160 supplier, Somatostatin, sst, Receptors, RC160, Vapreotide, 3139, Tocris Bioscience
Citations for RC 160
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