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Remodelin

Cat. No. 5193 Submit a Review Datasheet / COA / SDS
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Description: N-acetyltransferase 10 (NAT10) inhibitor
Chemical Name: 4-[2-(2-Cyclopentylidenehydrazinyl)-4-thiazolyl]benzonitrile
Purity: ≥99% (HPLC)
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Remodelin

Remodelin is a N-acetyltransferase 10 (NAT10) inhibitor. Improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells.

Technical Data for Remodelin

M. Wt 282.36
Formula C15H14N4S
Storage Store at +4°C
Purity ≥99% (HPLC)
CAS Number 949912-58-7
PubChem ID 44442376
InChI Key XAEJIFARBQJLML-UHFFFAOYSA-N
Smiles N#CC(C=C1)=CC=C1C2=CSC(N/N=C3CCCC/3)=N2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Remodelin

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 28.24 100

Preparing Stock Solutions for Remodelin

The following data is based on the product molecular weight 282.36. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.54 mL 17.71 mL 35.42 mL
5 mM 0.71 mL 3.54 mL 7.08 mL
10 mM 0.35 mL 1.77 mL 3.54 mL
50 mM 0.07 mL 0.35 mL 0.71 mL

Molarity Calculator

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References for Remodelin

References are publications that support the biological activity of the product.

Larrieu et al (2014) Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344 527 PMID: 24786082

If you know of a relevant reference for Remodelin, please let us know.

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Keywords: Remodelin, Remodelin supplier, NAT10, N-acetyltransferase, 10, aging, inhibitors, HGPS, Hutchinson-Gilford, progeria, syndrome, laminopathies, laminopathy, inhibits, Other, Transferases, 5193, Tocris Bioscience

Citations for Remodelin

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