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RETRA hydrochloride

Cat. No. 3214 Submit a Review Datasheet / COA / SDS

Discontinued Product

3214 has been discontinued.

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Description: Antitumor agent; suppresses mutant p53-bearing cancer cells
Chemical Name: 2-[(4,5-Dihydro-2-thiazolyl)thio]-1-(3,4-dihydroxyphenyl)ethanone hydrochloride
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Pathways (1)
Biological Activity Technical Data Datasheets References

Biological Activity for RETRA hydrochloride

RETRA hydrochloride is an antitumor agent. Inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and in vivo (IC50 = 4 μM). Transcriptionally activates expression of p53-responsive genes and induces activation of effector caspases 3 and 7.

Technical Data for RETRA hydrochloride

M. Wt 305.8
Formula C11N11NO3S2.HCl
Storage Desiccate at RT
Purity ≥99% (HPLC)
CAS Number 1173023-52-3
PubChem ID 46861546
InChI Key ZZAVDVMJZKDBIB-UHFFFAOYSA-N
Smiles OC1=CC(C(CSC2=NCCS2)=O)=CC=C1O.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for RETRA hydrochloride

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for RETRA hydrochloride

References are publications that support the biological activity of the product.

Kravchenko et al (2008) Small-molecule RETRA suppresses mutant p53-bearing cancer cells through a p73-dependent salvage pathway. Proc.Natl.Acad.Sci.USA 105 6302

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Citations for RETRA hydrochloride

Citations are publications that use Tocris products.

Currently there are no citations for RETRA hydrochloride.

Reviews for RETRA hydrochloride

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cell Cycle and DNA Damage Research Product Guide

Cell Cycle and DNA Damage Research Product Guide

This product guide provides a review of the cell cycle and DNA damage research area and lists over 150 products, including research tools for:

  • Cell Cycle and Mitosis
  • DNA Damage Repair
  • Targeted Protein Degradation
  • Ubiquitin Proteasome Pathway
  • Chemotherapy Targets
Cell Cycle & DNA Damage Repair Poster

Cell Cycle & DNA Damage Repair Poster

In normal cells, each stage of the cell cycle is tightly regulated, however in cancer cells many genes and proteins that are involved in the regulation of the cell cycle are mutated or over expressed. This poster summarizes the stages of the cell cycle and DNA repair. It also highlights strategies for enhancing replicative stress in cancer cells to force mitotic catastrophe and cell death.

Pathways for RETRA hydrochloride

p53 Signaling Pathway

p53 Signaling Pathway

p53 signaling plays an important role in the co-ordination of the cellular response different types of stress such as DNA damage and hypoxia. The downstream signals lead to apoptosis, senescence and cell cycle arrest.