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Submit ReviewRifaximin
Description: Pregnane X receptor agonist; antibiotic
Chemical Name: (2S,16Z,18E,20S,21S,22R,23R,24R,25S,26R,27S,28E)-25-(Acetyloxy)-5,6,21,23-tetrahydroxy-27-methoxy-2,4,11,16,20,22,24,26-octamethyl-2,7-(epoxypentadeca[1,11,13]trienimino)benzofuro[4,5-e]pyrido[1,2-a]benzimidazole-1,15(2H)-dione
Purity: ≥98% (HPLC)
Biological Activity for Rifaximin
Rifaximin is a pregnane X receptor (PXR) agonist; antibiotic. Reduces number of colon tumors and suppresses expression of TNFα and Il-1β induced in a colon cancer, PXR-humanized mouse model. Increases apoptosis and decreased proliferation in HT-29 cells. Exhibits low gastrointestinal absorption while retaining its antibacterial activity. Active against gram-positive and gram-negative bacteria.
Compound Libraries for Rifaximin
Rifaximin is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Rifaximin
| M. Wt | 785.88 |
| Formula | C43H51N3O11 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 80621-81-4 |
| PubChem ID | 6436173 |
| InChI Key | NZCRJKRKKOLAOJ-XRCRFVBUSA-N |
| Smiles | O=C(/C(C)=C\C=C\[C@H](C)[C@H](O)[C@H]([C@H]([C@@H](C)[C@H](OC(C)=O)[C@H](C)[C@@H](OC)/C=C/O[C@@]5(C)O4)O)C)NC2=C(O)C1=C(O)C(C)=C4C(C5=O)=C1C3=C2N6C(C=C(C)C=C6)=N3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Rifaximin
References for Rifaximin
References are publications that support the biological activity of the product.
Cheng et al (2014) Activation of intestinal human pregnane X receptor protects against azoxymethane/dextran sulfate sodium-induced colon cancer. J.Pharmacol.Exp.Ther. 351 559 PMID: 25277138
Jiang et al (2005) Rifaximin: in vitro and in vivo antibacterial activity-a review. Chemotherapy 51 67 PMID: 15855749
Stradi et al (2010) Structural elucidation of the rifa. Ph. Eur. Impurity H. J.Pharm.Biomed.Anal. 51 858 PMID: 19926422
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Keywords: Rifaximin, Rifaximin supplier, Antibiotic, Pregnane, X, receptors, agonists, PXR, colon, tumors, tumours, gram, positive, negative, bacteria, Receptor, Antibiotics, Apoptosis, Inducers, 5359, Tocris Bioscience
Citations for Rifaximin
Citations are publications that use Tocris products.
Currently there are no citations for Rifaximin.
Reviews for Rifaximin
Average Rating: 4 (Based on 1 Review.)
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Rifaximin used in resistance study against E.Coli.
By
Anonymous on 02/11/2019
Species: Human
Rifaximin was used against E.coli in comparison with Rifampine. Resistance study of E.coli was being carried out.
Literature in this Area
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Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.