Home / Pharmacology / Other Pharmacology / Sigma Receptors / σ2 Receptors / σ2 Receptor Antagonists / Rimcazole dihydrochloride

Rimcazole dihydrochloride

Cat. No. 1497 1 Citation Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: σ2 antagonist. Also DAT inhibitor
Alternative Names: BW 234U
Chemical Name: 9-[3-(cis-3,5-Dimethyl-1-piperazinyl)propyl]-9H-carbazole dihydrochloride
Purity: ≥98% (HPLC)
Datasheet
Citations (1)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Rimcazole dihydrochloride

Rimcazole dihydrochloride is an antagonist at σ receptors (IC50 values are 1480 and 386 nM at σ1 and σ2 receptors respectively). Also binds to the dopamine transporter (IC50 = 57.6 nM) and inhibits dopamine uptake. Reduces the stimulatory effects of cocaine in vivo.

Technical Data for Rimcazole dihydrochloride

M. Wt 394.39
Formula C21H27N3.2HCl
Storage Store at +4°C
Purity ≥98% (HPLC)
CAS Number 75859-03-9
PubChem ID 53388
InChI Key ZWHRZGHGYMUSRM-VWDRLOGHSA-N
Smiles C[C@H](N[C@H](C)C4)CN4CCCN1C3=C(C=CC=C3)C2=C1C=CC=C2.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Rimcazole dihydrochloride

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
water 3.94 10

Preparing Stock Solutions for Rimcazole dihydrochloride

The following data is based on the product molecular weight 394.39. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 25.36 mL 126.78 mL 253.56 mL
0.5 mM 5.07 mL 25.36 mL 50.71 mL
1 mM 2.54 mL 12.68 mL 25.36 mL
5 mM 0.51 mL 2.54 mL 5.07 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Rimcazole dihydrochloride

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Rimcazole dihydrochloride

References are publications that support the biological activity of the product.

Ferris et al (1986) Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci. 38 2329 PMID: 2873494

Husbands et al (1997) Isothiocyanate derivatives of 9-[3-(cis-3,5-dimethyl-1-piperazinyl)propyl]-carbazole (Rimcazole): irreversible ligands for the DA transporter. J.Med.Chem. 40 4340 PMID: 9435903

Matsumoto et al (2001) Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than DA transporters. Neuropharmacology 41 878 PMID: 11684152

If you know of a relevant reference for Rimcazole dihydrochloride, please let us know.

View Related Products by Target

View Related Products by Product Action

View all σ2 Receptor Antagonists

Keywords: Rimcazole dihydrochloride, Rimcazole dihydrochloride supplier, σ2, sigma2, antagonists, DAT, reuptake, inhibitors, inhibits, Receptors, Dopamine, Transporters, Monoamine, Neurotransmitter, BW234U, BW, 234U, Sigma2, 1497, Tocris Bioscience

1 Citation for Rimcazole dihydrochloride

Citations are publications that use Tocris products. Selected citations for Rimcazole dihydrochloride include:

Rennekamp et al (2016) σ1 receptor ligands control a switch between passive and active threat responses. Nat Chem Biol 12 552 PMID: 27239788

Do you know of a great paper that uses Rimcazole dihydrochloride from Tocris? Please let us know.

Reviews for Rimcazole dihydrochloride

There are currently no reviews for this product. Be the first to review Rimcazole dihydrochloride and earn rewards!

Have you used Rimcazole dihydrochloride?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review