Home / Pharmacology / Enzymes / Kinases / Receptor Interacting Protein Kinase Family / Receptor Interacting Protein Kinases / Receptor Interacting Protein Kinase Inhibitors / RIPK2 inhibitor 1

RIPK2 inhibitor 1

Cat. No. 6603 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent RIPK2 inhibitor
Chemical Name: 3-(Benzoylamino)-4-methyl-N-[3-(1-methyl-1H-imidazol-2-yl)phenyl]benzamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for RIPK2 inhibitor 1

RIPK2 inhibitor 1 is a potent receptor-interacting protein kinase 2 (RIPK2) inhibitor (IC50 of 5-10 nM). It inhibits NF-κB activity and decreases cancer cell proliferation by 70%. In vivo, RIPK2 inhibitor 1 inhibits intestinal and lung inflammation with low toxicity in rodent models.

Technical Data for RIPK2 inhibitor 1

M. Wt 410.48
Formula C25H22N4O2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 1290490-78-6
PubChem ID 99506096
InChI Key OIIYBZHRYXJCHR-UHFFFAOYSA-N
Smiles CN1C=CN=C1C2=CC(NC(C3=CC(NC(C4=CC=CC=C4)=O)=C(C)C=C3)=O)=CC=C2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RIPK2 inhibitor 1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 41.05 100

Preparing Stock Solutions for RIPK2 inhibitor 1

The following data is based on the product molecular weight 410.48. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.44 mL 12.18 mL 24.36 mL
5 mM 0.49 mL 2.44 mL 4.87 mL
10 mM 0.24 mL 1.22 mL 2.44 mL
50 mM 0.05 mL 0.24 mL 0.49 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for RIPK2 inhibitor 1

Certificate of Analysis / Product Datasheet
Safety Datasheet

References for RIPK2 inhibitor 1

References are publications that support the biological activity of the product.

Salla et al (2018) Identification and characterization of novel receptor-interacting serine/threonine-protein kinase 2 inhibitors using structural similarity analysis. J.Pharmacol.Exp.Ther. 365 354 PMID: 29555876

If you know of a relevant reference for RIPK2 inhibitor 1, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Receptor Interacting Protein Kinase Inhibitors

Keywords: RIPK2 inhibitor 1, RIPK2 inhibitor 1 supplier, TCMS1, anti, inflammatory, RIPK2, RIPK, RIP, kinase, inhibitors, inhibits, receptor-interacting, protein, 2, potent, in, vivo, Kinases, 6603, Tocris Bioscience

Citations for RIPK2 inhibitor 1

Citations are publications that use Tocris products.

Currently there are no citations for RIPK2 inhibitor 1. Do you know of a great paper that uses RIPK2 inhibitor 1 from Tocris? Please let us know.

Reviews for RIPK2 inhibitor 1

There are currently no reviews for this product. Be the first to review RIPK2 inhibitor 1 and earn rewards!

Have you used RIPK2 inhibitor 1?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review