Home / Pharmacology / Enzymes / Phosphodiesterases / Phosphodiesterase Inhibitors / Ro 20-1724

Ro 20-1724

Cat. No. 0415 3 Citations Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: PDE4 inhibitor
Chemical Name: 4-(3-Butoxy-4-methoxyphenyl)methyl-2-imidazolidone
Purity: ≥99% (HPLC)
Datasheet
Citations (3)
Reviews
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ro 20-1724

Ro 20-1724 is a widely used inhibitor of cyclic nucleotide phosphodiesterase, selective for PDE4 (IC50 = 2.0 μM).

Compound Libraries for Ro 20-1724

Ro 20-1724 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Ro 20-1724

M. Wt 278.35
Formula C15H22N2O3
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 29925-17-5
PubChem ID 5087
InChI Key PDMUULPVBYQBBK-UHFFFAOYSA-N
Smiles CCCCOC1=CC(CC2CNC(=O)N2)=CC=C1OC

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ro 20-1724

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
ethanol 27.84 100
DMSO 27.84 100

Preparing Stock Solutions for Ro 20-1724

The following data is based on the product molecular weight 278.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.59 mL 17.96 mL 35.93 mL
5 mM 0.72 mL 3.59 mL 7.19 mL
10 mM 0.36 mL 1.8 mL 3.59 mL
50 mM 0.07 mL 0.36 mL 0.72 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

Product Datasheets for Ro 20-1724

Certificate of Analysis / Product Datasheet
Select another batch:
Safety Datasheet

References for Ro 20-1724

References are publications that support the biological activity of the product.

Nicholson et al (1991) Differential modulation of tissue function and therapeutic potential of selective inhibitors of cyclic nucleotide phosphodiesterase isoenzymes. TiPS 12 19 PMID: 1848733

Reeves et al (1987) The identification of a new cyclic nucleotide phosphodiesterase activity in human and guinea-pig cardiac ventricle. Biochem.J. 241 535 PMID: 3036066

Soderling et al (1998) Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Proc.Natl.Acad.Sci.U.S.A. 95 8991 PMID: 9671792

If you know of a relevant reference for Ro 20-1724, please let us know.

View Related Products by Target

View Related Products by Product Action

View all Phosphodiesterase Inhibitors

Keywords: Ro 20-1724, Ro 20-1724 supplier, PDE4, inhibitors, inhibits, Phosphodiesterases, Ro20-1724, 0415, Tocris Bioscience

3 Citations for Ro 20-1724

Citations are publications that use Tocris products. Selected citations for Ro 20-1724 include:

Winger et al (2014) Rapid remodeling of tight junctions during paracellular diapedesis in a human model of the blood-brain barrier. J Immunol 193 2427 PMID: 25063869

Zhong et al (2012) Phosphodiesterase 4 inhibition impairs cocaine-induced inhibitory synaptic plasticity and conditioned place preference. Neuropsychopharmacology 37 2377 PMID: 22713909

Peters et al (2007) Evaluation of cellular dielectric spectroscopy, a whole-cell, label-free technology for drug discovery on Gi-coupled GPCRs. J Biomol Screen 12 312 PMID: 17307886

Do you know of a great paper that uses Ro 20-1724 from Tocris? Please let us know.

Reviews for Ro 20-1724

There are currently no reviews for this product. Be the first to review Ro 20-1724 and earn rewards!

Have you used Ro 20-1724?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review