Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRo 8-4304 hydrochloride
Description: GluN2B-selective NMDA antagonist
Chemical Name: 4-[3-[4-(4-Fluorophenyl)-1,2,3,6-tetrahydro-1(2H)-pyridinyl]-2-hydroxypropoxy]benzamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Ro 8-4304 hydrochloride
NMDA receptor antagonist (IC50 = 0.4 μM) that displays > 100 fold selectivity for GluN2B (formally NR2B) containing receptors over GluN2A (formally NR2A) containing receptors. Exhibits an activity-dependent mechanism of NMDA antagonism and is competitive with respect to spermine (Cat. No. 0958).
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Technical Data for Ro 8-4304 hydrochloride
| M. Wt | 406.88 |
| Formula | C21H23FN2O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1312991-77-7 |
| PubChem ID | 11957680 |
| InChI Key | MQOXWHKUQOFFJW-UHFFFAOYSA-N |
| Smiles | NC(C1=CC=C(OCC(O)CN2CCC(C3=CC=C(F)C=C3)=CC2)C=C1)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Ro 8-4304 hydrochloride
References for Ro 8-4304 hydrochloride
References are publications that support the biological activity of the product.
Kew et al (1998) State-dependent NMDA receptor antagonism by Ro 8-4304, a novel NR2B selective, non-competitive, voltage-independent antagonist. Br.J.Pharmacol. 123 463 PMID: 9504387
Kew and Kemp (1998) An allosteric interaction between the NMDA receptor polyamine and ifenprodil sites in rat cultured cortical neurones. J.Physiol. 512 17 PMID: 9729614
View Related Products by Target
View Related Products by Product Action
Keywords: Ro 8-4304 hydrochloride, Ro 8-4304 hydrochloride supplier, NR2B, selective, antagonists, NMDA, Receptors, Glutamate, Ionotropic, N-Methyl-D-Aspartate, iGluR, Ro8-4304, GluN2B, 3343, Tocris Bioscience
Citations for Ro 8-4304 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for Ro 8-4304 hydrochloride.
Reviews for Ro 8-4304 hydrochloride
There are currently no reviews for this product. Be the first to review Ro 8-4304 hydrochloride and earn rewards!
Have you used Ro 8-4304 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Huntington's Disease Research Product Guide
This product guide provides a background to Huntington's disease research and lists around 100 products for the study of:
- Somatic Instability
- Proteolysis and Inclusion Bodies
- Transcriptional Dysregulation
- Mitochondrial Dysfunction
- Nuclear-Cytoplasmic Transport Interference
- Excitotoxicity
- Stem Cells
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.