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Submit ReviewRS 16566 dihydrochloride
Description: 5-HT3 ligand; shows affinity for zacopride binding site
Chemical Name: (R)-N-1-Azabicyclo[2.2.2]oct-3-yl-6-chloro-1-(1-methylethyl)-1H-benzimidazole-4-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for RS 16566 dihydrochloride
RS 16566 dihydrochloride is a high affinity ligand for the (R)-zacopride binding site (pKi 9.84 ).
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data for RS 16566 dihydrochloride
| M. Wt | 419.78 |
| Formula | C18H23ClN4O.2HCl |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1217788-97-0 |
| PubChem ID | 90479748 |
| InChI Key | LPEOWDMQSXDYRJ-CKUXDGONSA-N |
| Smiles | ClC1=CC(C(N[C@@H]3C4CCN(CC4)C3)=O)=C2C(N(C(C)C)C=N2)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RS 16566 dihydrochloride
References for RS 16566 dihydrochloride
References are publications that support the biological activity of the product.
Flippin et al (1996) (R)-3-(6-Chloro-1-isopropylbenzimidazole-4-carboxamido)quinuclidine: a high affinity ligand for the (R)-zacopride binding site. Bioorg.Med.Chem.Lett. 6 477
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1 Citation for RS 16566 dihydrochloride
Citations are publications that use Tocris products. Selected citations for RS 16566 dihydrochloride include:
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. J Neurosci 7 2336 PMID: 26114334
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.