Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewRS 23597-190 hydrochloride
Description: 5-HT4 antagonist
Chemical Name: 3-(Piperidin-1-yl)propyl 4-amino-5-chloro-2-methoxybenzoate hydrochloride
Biological Activity for RS 23597-190 hydrochloride
RS 23597-190 hydrochloride is a high affinity, selective competitive antagonist at 5-HT4 receptors.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data for RS 23597-190 hydrochloride
| M. Wt | 363.28 |
| Formula | C16H23ClN2O3.HCl |
| Storage | Store at RT |
| CAS Number | 149719-06-2 |
| PubChem ID | 182592 |
| InChI Key | QLZLBYYNMGQIAR-UHFFFAOYSA-N |
| Smiles | Cl.COC1=CC(N)=C(Cl)C=C1C(=O)OCCCN1CCCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for RS 23597-190 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for RS 23597-190 hydrochloride
The following data is based on the product molecular weight 363.28. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.75 mL | 13.76 mL | 27.53 mL |
| 5 mM | 0.55 mL | 2.75 mL | 5.51 mL |
| 10 mM | 0.28 mL | 1.38 mL | 2.75 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.55 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for RS 23597-190 hydrochloride
References for RS 23597-190 hydrochloride
References are publications that support the biological activity of the product.
Eglen et al (1993) RS 23597-190: a potent and selective 5-HT4 receptor antagonist. Br.J.Pharmacol. 110 119 PMID: 8220871
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
If you know of a relevant reference for RS 23597-190 hydrochloride, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: RS 23597-190 hydrochloride, RS 23597-190 hydrochloride supplier, 5-HT4, antagonists, Serotonin, Receptors, 5-Hydroxytryptamine, 5-HT, RS23597-190, hydrochloride, 0728, Tocris Bioscience
5 Citations for RS 23597-190 hydrochloride
Citations are publications that use Tocris products. Selected citations for RS 23597-190 hydrochloride include:
Du et al (2015) Adrenergic and serotonin receptors affect retinal superoxide generation in diabetic mice: relationship to capillary degeneration and permeability. FASEB J 29 2194 PMID: 25667222
Kato et al (2006) Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats. J Neurosci 26 1787 PMID: 16467527
Xiang et al (2005) Modulation of spontaneous firing in rat subthalamic neurons by 5-HT receptor subtypes. J Neurophysiol 93 1145 PMID: 15738272
Woo et al (2007) Neuregulin-1 enhances depolarization-induced GABA release. Neuron 54 599 PMID: 17521572
Huang and Kandel (2007) 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Pharmacol Exp Ther 27 3111 PMID: 17376972
Do you know of a great paper that uses RS 23597-190 hydrochloride from Tocris? Please let us know.
Reviews for RS 23597-190 hydrochloride
There are currently no reviews for this product. Be the first to review RS 23597-190 hydrochloride and earn rewards!
Have you used RS 23597-190 hydrochloride?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.