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Submit ReviewRS 56812 hydrochloride
Description: 5-HT3 partial agonist
Chemical Name: (R)-N-(1-Azabicyclo[2.2.2]oct-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for RS 56812 hydrochloride
RS 56812 hydrochloride is a highly potent and selective 5-HT3 partial agonist, with a pKi at 5-HT3 receptors in rat brain of 9.6, and greater than 1000-fold selectivity over a wide range of other neurotransmitter receptors.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data for RS 56812 hydrochloride
| M. Wt | 347.84 |
| Formula | C18H21N3O2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 143339-12-2 |
| PubChem ID | 67858205 |
| InChI Key | NHWCYXITJPBOHX-RSAXXLAASA-N |
| Smiles | O=C(C(N[C@@H]3C(CC4)CCN4C3)=O)C1=CN(C)C2=C1C=CC=C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RS 56812 hydrochloride
References for RS 56812 hydrochloride
References are publications that support the biological activity of the product.
Clark et al (1995) N-(Quinuclidin-3-yl)-2-(1-methyl-1H-indol-3-yl)-2-oxoacetamide: a high affinity 5-HT3 receptor partial agonist. Bioorg.Med.Chem.Lett. 5 1853
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Keywords: RS 56812 hydrochloride, RS 56812 hydrochloride supplier, 5-HT3, partial, agonists, Serotonin, Receptors, RS56812, hydrochloride, 0988, Tocris Bioscience
1 Citation for RS 56812 hydrochloride
Citations are publications that use Tocris products. Selected citations for RS 56812 hydrochloride include:
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. Mol Psychiatry 7 2336 PMID: 26114334
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.