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Submit ReviewRS 67506 hydrochloride
Description: 5-HT4 partial agonist
Chemical Name: 1-(4-Amino-5-chloro-2-methoxyphenyl)-3-[1-2-methylsulphonylamino)ethyl-4-piperidinyl]-1-propanone hydrochloride
Biological Activity for RS 67506 hydrochloride
RS 67506 hydrochloride is a potent and selective 5-HT4 partial agonist, with a pKi of 8.8 at 5-HT4 sites in guinea pig striatum, but < 6.0 at several other receptors including 5-HT1A, 1D, 2A, 2C, D1, D2 and M1-3. It is active in vivo and has an intrinsic activity compared to 5-HT of 0.6.
Licensing Information
Sold with the permission of Roche Bioscience
Technical Data for RS 67506 hydrochloride
| M. Wt | 454.41 |
| Formula | C18H28ClN3O4S.HCl |
| Storage | Store at RT |
| CAS Number | 168986-61-6 |
| PubChem ID | 133075 |
| InChI Key | GFWKWEHKHLTRRF-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(C=C(Cl)C(N)=C1)C(=O)CCC1CCN(CCNS(C)(=O)=O)CC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for RS 67506 hydrochloride
Certificate of Analysis is currently unavailable on-line.
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References for RS 67506 hydrochloride
References are publications that support the biological activity of the product.
Eglen et al (1995) Pharmacological characterization of two novel and potent 5-HT4 receptor agonists, RS 67333 and RS 67506, in vitro and in vivo. Br.J.Pharmacol. 115 1387 PMID: 8564196
Eglen et al (1995) Central 5-HT4 receptors. TiPS 16 391 PMID: 8578609
Fontana et al (1997) The effects of novel, selective 5-hydroxytryptamine (5HT)4 ligands in rat spatial navigation. Neuropharmacology 36 689 PMID: 9225295
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Keywords: RS 67506 hydrochloride, RS 67506 hydrochloride supplier, 5-HT4, partial, agonists, Serotonin, Receptors, 5-Hydroxytryptamine, RS67506, hydrochloride, 0990, Tocris Bioscience
1 Citation for RS 67506 hydrochloride
Citations are publications that use Tocris products. Selected citations for RS 67506 hydrochloride include:
Garavaglia et al (2010) Adaptation of NS cells growth and differentiation to high-throughput screening-compatible plates. BMC Neurosci 11 7 PMID: 20085655
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.