Home / Pharmacology / Ion Channels / Potassium Channels / Voltage-gated Potassium (KV) Channels / Voltage-gated Potassium (KV) Channel Blockers / RuBi-4AP

RuBi-4AP

Cat. No. 3557 Submit a Review Datasheet / COA / SDS

Discontinued Product

3557 has been discontinued.

View all Voltage-gated Potassium (K<sub>V</sub>) Channels products.
Description: Caged 4-aminopyridine; a non-selective KV channel blocker
Alternative Names: Rubi-4-aminopyridine
Chemical Name: bis(2,2'-Bipyridine-N,N')bis(4-aminopyridine-N1) ruthenium(2+) dichloride complex
Datasheet
Citations
Reviews
Biological Activity Technical Data Datasheets References

Biological Activity for RuBi-4AP

Water soluble ruthenium-bipyridine-triphenylphosphine caged 4-aminopyridine (4-AP). Excited by visible wavelengths and has two-photon uncaging capabilities under physiological conditions. Releases 4-AP (Cat. No. 0940), a voltage-dependent K+ channel blocker.

Licensing Information

Sold under licence from Columbia University

Technical Data for RuBi-4AP

M. Wt 672.58
Formula C30H28Cl2N8Ru
Storage Store at -20°C
CAS Number 851956-02-0
PubChem ID 11422486
InChI Key MVEGPXUCOGNVKR-UHFFFAOYSA-L
Smiles [Cl-].[Cl-].[Ru++].NC1=CC=NC=C1.NC1=CC=NC=C1.C1=CN=C(C=C1)C1=CC=CC=N1.C1=CC=C(N=C1)C1=CC=CC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RuBi-4AP

References are publications that support the biological activity of the product.

Zayat et al (2003) A new strategy for neurochemical photodelivery: Metal-ligand heterolytic cleavage. J.Am.Chem.Soc. 125 882 PMID: 12537482

Nikolenko et al (2005) Two-photon uncaging of neurochemicals using inorganic metal complexes. Chem.Commun. 13 1752

View Related Products by Target

View Related Products by Product Action

View all Voltage-gated Potassium (KV) Channel Blockers

Keywords: RuBi-4AP, RuBi-4AP supplier, voltage-dependent, gated, K+, potassium, channel, blockers, caged, 4-aminopyridine, hERG, Human, Ether-A-Go-Go, Gene, KCNQ, Rubi-4-aminopyridine, Voltage-Gated, Potassium, Channels, Other, Caged, Compounds, 3557, Tocris Bioscience

Citations for RuBi-4AP

Citations are publications that use Tocris products.

Currently there are no citations for RuBi-4AP.

Reviews for RuBi-4AP

There are currently no reviews for this product. Be the first to review RuBi-4AP and earn rewards!

Have you used RuBi-4AP?

Submit a review and receive an Amazon gift card.

$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review