RWJ 50271

Discontinued Product

4227 has been discontinued.

View all Integrins products.
Description: Inhibitor of LFA-1/ICAM mediated cell adhesion
Chemical Name: N-(3-Hydroxypropyl)-5-methyl-1-[-4-[3-(trifluoromethyl)phenyl)]-2-thiazolyl]-1H-pyrazole-4-carboxamide
Purity: ≥99% (HPLC)
Datasheet
Citations (1)
Reviews
Literature (2)

Biological Activity for RWJ 50271

RWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).

Technical Data for RWJ 50271

M. Wt 410.41
Formula C18H17F3N4O2S
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 162112-37-0
PubChem ID 9953357
InChI Key HOFGTYCLOKDAES-UHFFFAOYSA-N
Smiles CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for RWJ 50271

References are publications that support the biological activity of the product.

Sanfilippo et al (1995) Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 38 1057 PMID: 7707308

Keywords: RWJ 50271, RWJ 50271 supplier, RWJ50271, inhibitors, inhibits, LFA-1/ICAM-1, adhesion, sICAM, lymphocyte, function-associated, antigen-1, Integrins, Cell, Adhesion, Molecules, 4227, Tocris Bioscience

1 Citation for RWJ 50271

Citations are publications that use Tocris products. Selected citations for RWJ 50271 include:

Takizawa (2017) Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture. Exp Cell Res 358 441 PMID: 28712928


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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Angiogenesis in Cancer Poster

Angiogenesis in Cancer Poster

This poster summarizes the pathogenesis of angiogenesis in cancer, as well as some of the main angiogenesis therapeutic targets.

Enabling Research By Provision of Chemical Tools Poster

Enabling Research By Provision of Chemical Tools Poster

The Tocris chemistry team has considerable chemistry knowledge and skill which it has recently been applying to the generation of new chemical probes from known tools and compounds to help answer biological questions. This poster presents some of the work carried out by Tocris scientists and focuses on two areas: the generation of libraries of chemical building blocks to support Degrader (PROTAC) research and the development of a fluorescent probe to study integrin biology. Presented at Chemical Tools for Complex Biological Systems II, 2019, Janelia Research Campus, USA.