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Submit ReviewRWJ 50271 is a selective inhibitor of LFA-1 (lymphocyte function-associated antigen-1) adhesion to soluble intercellular adhesion molecule (sICAM) (IC50 = 5 μM in HL60 cells).
M. Wt | 410.41 |
Formula | C18H17F3N4O2S |
Storage | Store at RT |
Purity | ≥99% (HPLC) |
CAS Number | 162112-37-0 |
PubChem ID | 9953357 |
InChI Key | HOFGTYCLOKDAES-UHFFFAOYSA-N |
Smiles | CC1=C(C(NCCCO)=O)C=NN1C2=NC(C3=CC(C(F)(F)F)=CC=C3)=CS2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
References are publications that support the biological activity of the product.
Sanfilippo et al (1995) Novel thiazole based heterocycles as inhibitors of LFA-1/ICAM-1 mediated cell adhesion. J.Med.Chem. 38 1057 PMID: 7707308
Keywords: RWJ 50271, RWJ 50271 supplier, RWJ50271, inhibitors, inhibits, LFA-1/ICAM-1, adhesion, sICAM, lymphocyte, function-associated, antigen-1, Integrins, Cell, Adhesion, Molecules, 4227, Tocris Bioscience
Citations are publications that use Tocris products. Selected citations for RWJ 50271 include:
Takizawa (2017) Bone marrow-derived mesenchymal stem cells propagate immunosuppressive/anti-inflammatorymacrophages in cell-to-cell contact-independent and dependent manners under hypoxic culture. Exp Cell Res 358 441 PMID: 28712928
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