RWJ 56110

Cat. No. 2614 5 Citations Submit a Review Datasheet / COA / SDS

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Description: Selective PAR₁ antagonist

Chemical Name: (αS)-N-[(1S)-3-Amino-1-[[(phenylmethyl)amino]carbonyl]propyl]-α-[[[[1-[(2,6-dichlorophenyl)methyl]-3-(1-pyrrolidinylmethyl)-1H-indol-6-yl]amino]carbonyl]amino]-3,4-difluoro-benzenepropanamide

Purity: ≥96% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for RWJ 56110

RWJ 56110 is a selective protease-activated receptor-1 (PAR₁) antagonist; displays no activity at PAR₂, PAR₃, or PAR₄ subtypes. Blocks thrombin-induced platelet aggregation and activation of MAPK in HUVECs. Also inhibits angiogenesis in a chick embryo angiogenesis model in vivo.

Technical Data for RWJ 56110

M. Wt	863.65
Formula	C₄₁H₄₃Cl₂F₂N₇O₃.2HCl
Storage	Store at -20°C
Purity	≥96% (HPLC)
CAS Number	2387505-58-8
PubChem ID	90488773
InChI Key	MGZSVSHDIOPSBO-ZEUUMAKDSA-N
Smiles	ClC1=CC=CC(Cl)=C1CN3C2=CC(NC(N[C@@H](CC5=CC(F)=C(F)C=C5)C(N[C@@H](CCN)C(NCC6=CC=CC=C6)=O)=O)=O)=CC=C2C(CN4CCCC4)=C3.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for RWJ 56110

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	21.59	25
	DMSO	86.36	100

Preparing Stock Solutions for RWJ 56110

The following data is based on the product molecular weight 863.65. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.16 mL	5.79 mL	11.58 mL
5 mM	0.23 mL	1.16 mL	2.32 mL
10 mM	0.12 mL	0.58 mL	1.16 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

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Product Datasheets for RWJ 56110

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for RWJ 56110

References are publications that support the biological activity of the product.

Maryanoff et al (2003) Discovery of potent peptide-mimetic antagonists for the human thrombin receptor, protease-activated receptor-1 (PAR-1). Curr.Med.Chem.Cardiovasc.Hematol.Agents 1 13 PMID: 15317288

Zania et al (2006) Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J.Pharmacol.Exp.Ther. 318 246 PMID: 16595737

Andrade-Gordon et al (1999) Design, synthesis and biological characterization of a peptide-mimetic antagonist for a tethered-ligand receptor. Proc.Natl.Acad.Sci.USA 96 12257 PMID: 10535908

If you know of a relevant reference for RWJ 56110, please let us know.

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Keywords: RWJ 56110, RWJ 56110 supplier, selective, PAR1, antagonists, PAR, receptors, protease-activated, proteinase-activated, RWJ56110, 252889-88-6, Protease-Activated, Receptors, 2614, Tocris Bioscience