Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewS 107 hydrochloride
Discontinued Product
3893 has been discontinued.
View all General Calcium Signaling Agents products.
Description: RyR1 stabilizer; inhibits Ca2+ leak from the SR
Chemical Name: 2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for S 107 hydrochloride
Type 1 ryanodine receptor (RyR1) stabilizer; binds RyR1 and enhances the binding affinity of calstabin-1. Inhibits Ca2+ leak from the sarcoplasmic reticulum (SR). Activity results in improved muscle function and increased exercise performance in a Duchenne muscular dystrophy (DMD) mouse model (mdx). Also reduces exercise-induced muscle damage by lowering calpain activation and plasma creatine kinase levels.
Technical Data for S 107 hydrochloride
| M. Wt | 245.77 |
| Formula | C11H15NOS.HCl |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 927871-76-9 |
| Smiles | CN2CCSC1=CC=C(OC)C=C1C2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for S 107 hydrochloride
References for S 107 hydrochloride
References are publications that support the biological activity of the product.
Bellinger et al (2008) Remodeling of ryanodine receptor complex causes "leaky" channels: a molecular mechanism for decreased exercise capacity. Proc.Natl.Acad.Sci. 105 2198
Bellinger et al (2009) Hypernitrosylated ryanodine receptor/calcium release channels are leaky in dystrophic muscle. Nature Med. 15 325
View Related Products by Target
Keywords: S 107 hydrochloride, S 107 hydrochloride supplier, ryanodine, receptors, RyR1inhibits, inhibitors, calcium, Ca2+, leak, sarcoplasmic, reticulum, muscle, function, damage, S107, General, Calcium, Signaling, Agents, 3893, Tocris Bioscience
Citations for S 107 hydrochloride
Citations are publications that use Tocris products.
Currently there are no citations for S 107 hydrochloride.
Reviews for S 107 hydrochloride
There are currently no reviews for this product. Be the first to review S 107 hydrochloride and earn rewards!
Have you used S 107 hydrochloride?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image