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Submit ReviewS 18886
Description: Potent thromboxane A2 (TP) antagonist
Alternative Names: terutroban
Chemical Name: (6R)-6-[[(4-Chlorophenyl)sulfonyl]amino]-5,6,7,8-tetrahydro-2-methyl-1-naphthalenepropanoic acid
Purity: ≥98% (HPLC)
Biological Activity for S 18886
S 18886 is a potent thromboxane A2 (TP) inhibitor (IC50 = 16.4 nM). Inhibits U 46619 (Cat. No. 1932) induced human platelet aggregation and contraction of isolated rabbit saphenous vein in vitro. Also inhibits U 46619 induced increase in tracheal pressure in guinea pigs. Orally available.
Compound Libraries for S 18886
S 18886 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for S 18886
| M. Wt | 407.91 |
| Formula | C20H22ClNO4S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 165538-40-9 |
| PubChem ID | 9938840 |
| InChI Key | HWEOXFSBSQIWSY-MRXNPFEDSA-N |
| Smiles | CC1=CC=C(C[C@H](NS(C2=CC=C(Cl)C=C2)(=O)=O)CC3)C3=C1CCC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for S 18886
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 40.79 | 100 | |
| ethanol | 8.16 | 20 with gentle warming |
Preparing Stock Solutions for S 18886
The following data is based on the product molecular weight 407.91. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.45 mL | 12.26 mL | 24.52 mL |
| 5 mM | 0.49 mL | 2.45 mL | 4.9 mL |
| 10 mM | 0.25 mL | 1.23 mL | 2.45 mL |
| 50 mM | 0.05 mL | 0.25 mL | 0.49 mL |
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Product Datasheets for S 18886
References for S 18886
References are publications that support the biological activity of the product.
Cimetière et al (1998) Synthesis and biological evaluation of new tetrahydronaphthalene derivatives as thromboxane receptor antagonists. Bioorg.Med.Chem.Lett. 8 1375 PMID: 9871769
Wang et al (2014) Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. ACS Med.Chem.Lett. 5 1015 PMID: 25221659
If you know of a relevant reference for S 18886, please let us know.
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Keywords: S 18886, S 18886 supplier, S18886, terutroban, thromboxane, A2, antagonist, platelet, aggregation, orally, availalble, prostanoids, inhibitors, inhibits, Prostanoid, Receptors, 5568, Tocris Bioscience
Citations for S 18886
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