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Submit ReviewS 2101
Description: LSD1 inhibitor
Chemical Name: (1R,2S)-rel-2-[3,5-Difluoro-2-(phenylmethoxy)phenyl]cycloprpanamine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for S 2101
S 2101 is a LSD1 inhibitor (IC50 = 990 nM; Ki = 610 nM). Exhibits selectivity for LSD1 over MAO-B and MAO-A (Ki values are 17 and 110 μM, respectively).
Technical Data for S 2101
| M. Wt | 311.75 |
| Formula | C16H15F2NO.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1239262-36-2 |
| PubChem ID | 121513887 |
| InChI Key | CTSUZAFTJVLOIX-SBKWZQTDSA-N |
| Smiles | FC1=CC([C@@H]2C[C@H]2N)=C(OCC3=CC=CC=C3)C(F)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for S 2101
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 15.59 | 50 | |
| DMSO | 31.18 | 100 |
Preparing Stock Solutions for S 2101
The following data is based on the product molecular weight 311.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.21 mL | 16.04 mL | 32.08 mL |
| 5 mM | 0.64 mL | 3.21 mL | 6.42 mL |
| 10 mM | 0.32 mL | 1.6 mL | 3.21 mL |
| 50 mM | 0.06 mL | 0.32 mL | 0.64 mL |
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Product Datasheets for S 2101
References for S 2101
References are publications that support the biological activity of the product.
Mimasu et al (2010) Structurally designed trans-2-phenylcyclopropylamine derivatives potently inhibit histone demethylase LSD1/KDM1. Biochemistry 49 6494 PMID: 20568732
If you know of a relevant reference for S 2101, please let us know.
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Keywords: S 2101, S 2101 supplier, S2101, LSD1, inhibitors, inhibits, histones, demethylases, KDM1, Histone, Demethylases, 5714, Tocris Bioscience
1 Citation for S 2101
Citations are publications that use Tocris products. Selected citations for S 2101 include:
Chris et al (2020) Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1. Elife 9 PMID: 33350386
Do you know of a great paper that uses S 2101 from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.