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Submit ReviewSalinomycin sodium salt
Description: Antibiotic; also selectively inhibits cancer stem cells
Chemical Name: (2R)-2-[(2R,5S,6R)-6-[(3S,5S,7R,9S,10S,12R,15R)-3-[(2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyloxan-2-yl]-15-hydroxy-3,10,12-trimethyl-4,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl]-3-hydroxy-4-methyl-5-oxooctan-2-yl]-5-methyloxan-2-yl]butanoic acid soldium salt
Biological Activity for Salinomycin sodium salt
Cytotoxic to breast cancer stem cells. Inhibits CD44 expression in breast cancer cells in vitro. Inhibits mammary tumor growth in mice. Also antibiotic.
Technical Data for Salinomycin sodium salt
| M. Wt | 772.98 |
| Formula | C42H69NaO11 |
| Storage | Store at +4°C |
| CAS Number | 55721-31-8 |
| PubChem ID | 45479870GC |
| InChI Key | GCVPRXBFNOZQIX-MMUBVBEESA-M |
| Smiles | C[C@@H]1[C@@]([C@@H](C)[C@H](O)[C@H](C)C([C@H](CC)[C@]2([H])[C@@H](C)C[C@@H](C)[C@]3(O[C@@]4(CC[C@]([C@@]5([H])CC[C@@](CC)(O)[C@H](C)O5)(C)O4)[C@H](O)C=C3)O2)=O)([H])O[C@]([C@@H](CC)C([O-])=O)([H])CC1.[Na+] |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Salinomycin sodium salt
References for Salinomycin sodium salt
References are publications that support the biological activity of the product.
Gupta et al (2009) Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell 138 645 PMID: 19682730
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