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Submit ReviewSalvinorin B
Description: Activator of κ-opioid DREADD (KORD)
Chemical Name: (2S,4aR,6aR,7R,9S,10aS,10bR)-2-(3-Furanyl)dodecahydro-9-hydroxy-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
Purity: ≥98% (HPLC)
Biological Activity for Salvinorin B
Salvinorin B is a potent and selective κ-opioid DREADD (KORD) activator (EC50 = 11.8 nM). Selective for KORD over endogenous κ opioid receptor and a range of other related targets. Exhibits no analgesic or ataxic effects in wild type mice. Induces neuronal hyperpolarization, and modifies locomotor activity and feeding behavior in KORD-expressing mouse models. Brain penetrant. Metabolite of salvinorin A.
Technical Data for Salvinorin B
| M. Wt | 390.43 |
| Formula | C21H26O7 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 92545-30-7 |
| PubChem ID | 11440685 |
| InChI Key | BLTMVAIOAAGYAR-CEFSSPBYSA-N |
| Smiles | O=C3[C@]2([H])CC[C@@]([C@]([H])1[C@](C)2C[C@@H]([C@]4=COC=C4)O3)(C)[C@H]([C@@](OC)=O)C[C@H](O)C1=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Salvinorin B
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.81 | 20 |
Preparing Stock Solutions for Salvinorin B
The following data is based on the product molecular weight 390.43. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 12.81 mL | 64.03 mL | 128.06 mL |
| 1 mM | 2.56 mL | 12.81 mL | 25.61 mL |
| 2 mM | 1.28 mL | 6.4 mL | 12.81 mL |
| 10 mM | 0.26 mL | 1.28 mL | 2.56 mL |
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Product Datasheets for Salvinorin B
References for Salvinorin B
References are publications that support the biological activity of the product.
Vardy et al (2015) A new DREADD facilitates the multiplexed chemogenetic interrogation of behavior. Neuron 86 936 PMID: 25937170
Ansonoff et al (2006) Antinociceptive and hypothermic effects of Salvinorin A are abolished in a novel strain of κ-opioid receptor-1 knockout mice. J.Pharmacol.Exp.Ther. 318 641 PMID: 16672569
If you know of a relevant reference for Salvinorin B, please let us know.
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Keywords: Salvinorin B, Salvinorin B supplier, Activates, κ-opioid, designer, receptors, drugs, KORD, DREADDs, salvinorin, A, agonists, agonism, chemogenetics, Kappa, Opioid, Receptors, 5611, Tocris Bioscience
4 Citations for Salvinorin B
Citations are publications that use Tocris products. Selected citations for Salvinorin B include:
Xiong et al (2021) Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function Cell Stem Cell 28 112 PMID: 32966778
Yun Ha et al (2020) Dopaminergic Regulation of Nucleus Accumbens Cholinergic Interneurons Demarcates Susceptibility to Cocaine Addiction. Biol Psychiatry 88 746-757 PMID: 32622465
Smith et al (2016) DREADDS: Use and application in behavioral neuroscience. Behav Neurosci 130 137 PMID: 26913540
Pina et al (2020) The kappa opioid receptor modulates GABA neuron excitability and synaptic transmission in midbrain-projections from the insular cortex. Neuropharmacology 165 107831 PMID: 31870854
Do you know of a great paper that uses Salvinorin B from Tocris? Please let us know.
Reviews for Salvinorin B
Average Rating: 5 (Based on 1 Review.)
Have you used Salvinorin B?
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Great version that works reliably.
By
Melanie Pina on 12/22/2019
Assay Type: Ex Vivo
Species: Human
Cell Line/Tissue: neuron
Great version that is easily dissolved in DMSO. Worked well in slice electrophysiology and produced reliable hyperpolarization in neurons expressing KOR DREADD at 100 nM.
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Chemogenetics Research Bulletin
Produced by Tocris, the chemogenetics research bulletin provides an introduction to chemogenetic methods to manipulate neuronal activity. It outlines the development of RASSLs, DREADDs and PSAMs, and the use of chemogenetic compounds. DREADD ligands and PSEMs available from Tocris are highlighted.
Allosteric GPCR Pharmacology Poster
G protein-coupled receptors (GPCRs) are intrinsically allosteric proteins. This poster provides insights into allosteric mechanisms of GPCR biology, highlighting key facets of GPCR allostery and therapeutic applications of allosteric modulators.
GPCR Efficacy and Biased Agonism Poster
GPCRs can interact with multiple distinct transducers or regulatory proteins and these can be preferentially engaged in an agonist-specific manner giving rise to biased agonism. This poster discusses cutting edge GPCR signaling pharmacology and highlights therapeutic applications of biased agonism.