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Submit ReviewSAR 216471 hydrochloride
Description: Potent P2Y12 antagonist; orally available
Chemical Name: 5-Chloro-N-[6-[5-methyl-4-(1-oxobutyl)-1H-pyrazol-1-yl]-3-pyridazinyl]-1-[2-(4-methyl-1-piperazinyl)-2-oxoethyl]-1H-indole-3-carboxamide hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for SAR 216471 hydrochloride
SAR 216471 hydrochloride is a potent P2Y12 antagonist (IC50 = 17 nM). Displays antiplatelet and antithrombotic activity in vivo. Orally available.
Technical Data for SAR 216471 hydrochloride
| M. Wt | 599.51 |
| Formula | C28H31ClN8O3.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 1279829-64-9 |
| PubChem ID | 70926954 |
| InChI Key | UQLWHBMSQKUYAI-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C2C(C(C(NC3=CC=C(N4C(C)=C(C(CCC)=O)C=N4)N=N3)=O)=CN2CC(N5CCN(C)CC5)=O)=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SAR 216471 hydrochloride
References for SAR 216471 hydrochloride
References are publications that support the biological activity of the product.
Boldron et al (2014) N-[6-(4-butanoyl-5-methyl-1H-pyrazol-1-yl)pyridazin-3-yl]-5-chloro-1-[2-(4-methylpiperazin-1-yl)-2-oxoethyl]-1H-indole-3-carboxamide (SAR216471), a novel intravenous and oral, reversible, and directly acting P2Y12 antagonist. J.Med.Chem. 57 7293 PMID: 25075638
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Keywords: SAR 216471 hydrochloride, SAR 216471 hydrochloride supplier, SAR216471, hydrochloride, potent, P2Y12, antagonists, antiplatelets, antithrombotics, orally, available, bioavailable, purine, receptors, purinoceptors, purinergic, antagonises, inhibitors, inhibits, Purinergic, P2Y, Receptors, 5650, Tocris Bioscience
1 Citation for SAR 216471 hydrochloride
Citations are publications that use Tocris products. Selected citations for SAR 216471 hydrochloride include:
Liu et al (2018) Salvianolic acids from antithrombotic Traditional Chinese Medicine Danshen are antagonists of human P2Y1 and P2Y12 receptors. Sci Rep 8 11380 PMID: 30038283
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.