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Submit ReviewSB 268262
Discontinued Product
4314 has been discontinued.
View all Calcitonin and Related Receptors products.
Description: Selective non-peptide CGRP antagonist
Chemical Name: N-Methyl-N-(2-methylphenyl)-3-nitro-4-(2-thiazolylsulfinyl)-benzamide
Purity: ≥99% (HPLC)
Biological Activity for SB 268262
SB 268262 is a selective non-peptide CGRP1 antagonist. Inhibits [125I]CGRP binding and CGRP-activated adenylyl cyclase stimulation in SK-N-MC cell membranes (IC50 values are 0.24 and 0.83 nM respectively).
Licensing Information
Sold with the permission of GlaxoSmithKline.
Technical Data for SB 268262
| M. Wt | 401.46 |
| Formula | C18H15N3O4S2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 217438-17-0 |
| PubChem ID | 6918567 |
| InChI Key | YXHLPJQQPOMPGE-UHFFFAOYSA-N |
| Smiles | O=S(C2=NC=CS2)C1=CC=C(C(N(C)C3=CC=CC=C3C)=O)C=C1[N+]([O-])=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SB 268262
References for SB 268262
References are publications that support the biological activity of the product.
Aiyar et al (2001) Pharmacology of SB-273779, a nonpeptide calcitonin gene-related peptide 1 receptor antagonist. J.Pharmacol.Exp.Ther. 296 768 PMID: 11181905
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Keywords: SB 268262, SB 268262 supplier, SB268262, CGRP, receptor, antagonist, calcitonin, gene-related, peptide, 1, antagonists, CGRP1, Calcitonin, and, Related, Receptors, 4314, Tocris Bioscience
1 Citation for SB 268262
Citations are publications that use Tocris products. Selected citations for SB 268262 include:
Matthias et al (2021) Substance P and Alpha-Calcitonin Gene-Related Peptide Differentially Affect Human Osteoarthritic and Healthy Chondrocytes. Front Immunol 12 722884 PMID: 34512650
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Peptides Involved in Appetite Modulation Scientific Review
Written by Sonia Tucci, Lynsay Kobelis and Tim Kirkham, this review provides a synopsis of the increasing number of peptides that have been implicated in appetite regulation and energy homeostasis; putative roles of the major peptides are outlined and compounds available from Tocris are listed.