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SB 297006

Cat. No. 4213 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: Potent and selective CCR3 antagonist
Chemical Name: N-Benzoyl-4-nitroaniline ethyl ester
Purity: ≥99% (HPLC)
Datasheet
Citations
Reviews
Literature (1)
Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for SB 297006

SB 297006 is a potent and selective CCR3 antagonist (IC50 = 39 nM). Displays 250-fold selectivity for CCR3 over other chemokine receptors, including CXCR1, CXCR2, CCR1 and CCR7 (IC50 >27 μM). Inhibits calcium mobilization induced by MCP-4, eotaxin-2 and eotaxin in RBL-2H3 cells transfected with CCR3 (IC50 values are 80, 90 and 210 nM respectively).

Compound Libraries for SB 297006

SB 297006 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.

Technical Data for SB 297006

M. Wt 342.35
Formula C18H18N2O5
Storage Store at RT
Purity ≥99% (HPLC)
CAS Number 58816-69-6
PubChem ID 9840971
InChI Key BEZXGSZPWXRHIN-INIZCTEOSA-N
Smiles O=C(C2=CC=CC=C2)N[C@H](C(OCC)=O)CC1=CC=C([N+]([O-])=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for SB 297006

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 34.23 100
ethanol 6.85 20

Preparing Stock Solutions for SB 297006

The following data is based on the product molecular weight 342.35. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 2.92 mL 14.6 mL 29.21 mL
5 mM 0.58 mL 2.92 mL 5.84 mL
10 mM 0.29 mL 1.46 mL 2.92 mL
50 mM 0.06 mL 0.29 mL 0.58 mL

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Reconstitution Calculator

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References for SB 297006

References are publications that support the biological activity of the product.

Yoshimoto and Hansch (1976) Quantitative structure-activity relationships of D- and L-N-actyl-alpha-aminoamide ligands binding to chymotrypsin. On the problem of combined treatment of stereoisomers. J.Org.Chem. 41 2269 PMID: 932854

White et al (2000) Identification of a potent, selective non-peptide CC chemokine receptor-3 antagonist that inhibits eotaxin-, eotaxin-2-, and monocyte chemotactic protein-4-induced eosinophil migration. J.Biol.Chem. 275 36626 PMID: 10969084

If you know of a relevant reference for SB 297006, please let us know.

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Citations for SB 297006

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Literature in this Area

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