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Submit ReviewSB 706375
Description: High affinity, non-peptide UT receptor antagonist
Chemical Name: 2-Bromo-4,5-dimethoxy-N-[3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for SB 706375
SB 706375 is a high affinity, non-peptide antagonist of the urotensin-II (UT) receptor. Exhibits high affinity for mammalian UT receptors, including human, mouse and rat (Ki values are 9.3, 19.1 and 20.7 nM respectively, in HEK293 cells expressing recombinant UT receptors). Also inhibits binding of radiolabeled urotensin to endogenous human UT receptors (Ki = 5.4 nM in a whole-cell binding assay). Displays ≥100-fold selectivity for the human UT receptor over 86 different receptors, ion channels, enzymes, transporters and nuclear hormones.
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline.
Technical Data for SB 706375
| M. Wt | 539.36 |
| Formula | C20H22BrF3N2O5S |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 733734-61-7 |
| PubChem ID | 21023902 |
| InChI Key | BPOWQJYAMDEAFF-CYBMUJFWSA-N |
| Smiles | BrC1=CC(OC)=C(OC)C=C1S(NC2=CC=C(C(F)(F)F)C(O[C@H]3CN(C)CC3)=C2)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SB 706375
References for SB 706375
References are publications that support the biological activity of the product.
Douglas et al (2005) Nonpeptidic urotensin-II receptor antagonists I: in vitro pharmacological characterization of SB-706375. Br.J.Pharmacol. 145 620 PMID: 15852036
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Keywords: SB 706375, SB 706375 supplier, SB706375, urotensin-II, U-II, receptors, UT, antagonists, high, affinity, Urotensin-II, Receptors, 4667, Tocris Bioscience
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