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Submit ReviewSC 560
Description: Cyclooxygenase-1 (COX-1) inhibitor
Chemical Name: 5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole
Purity: ≥98% (HPLC)
Biological Activity for SC 560
SC 560 is a highly selective cyclooxygenase-1 (COX-1) inhibitor (IC50 values are 0.009 and 6.3 μM for COX-1 and COX-2 respectively). Inhibits COX-1-derived platelet thromboxane B2, gastric PGE2 and dermal PDE2 production. Significantly reduces ovarian surface epithelial tumor growth in vivo. Orally active.
Technical Data for SC 560
| M. Wt | 352.74 |
| Formula | C17H12ClF3N2O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 188817-13-2 |
| PubChem ID | 4306515 |
| InChI Key | PQUGCKBLVKJMNT-UHFFFAOYSA-N |
| Smiles | COC1=CC=C(C=C1)N1N=C(C=C1C1=CC=C(Cl)C=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SC 560
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 35.27 | 100 | |
| ethanol | 8.82 | 25 |
Preparing Stock Solutions for SC 560
The following data is based on the product molecular weight 352.74. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.83 mL | 14.17 mL | 28.35 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.67 mL |
| 10 mM | 0.28 mL | 1.42 mL | 2.83 mL |
| 50 mM | 0.06 mL | 0.28 mL | 0.57 mL |
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Product Datasheets for SC 560
References for SC 560
References are publications that support the biological activity of the product.
Daikoku et al (2005) Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer. Cancer Res. 65 3735 PMID: 15867369
Takeuchi et al (2005) COX inhibition and NSAID-induced gastric damage - roles in various pathogenic events. Curr.Top.Med.Chem. 5 475 PMID: 15974942
Smith et al (1998) Pharmacological analysis of cyclooxygenase-1 in inflammation. Proc Natl Acad Sci U S A 95 13313 PMID: 9789085
If you know of a relevant reference for SC 560, please let us know.
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Keywords: SC 560, SC 560 supplier, Cyclooxygenase, COX-1, inhibitors, inhibits, Oxygenases, Oxidases, SC560, 1550, Tocris Bioscience
1 Citation for SC 560
Citations are publications that use Tocris products. Selected citations for SC 560 include:
Fritz et al (2016) Prostaglandin-dependent modulation of DArgic neurotransmission elicits inflammation-induced aversion in mice. J Clin Invest 126 695 PMID: 26690700
Do you know of a great paper that uses SC 560 from Tocris? Please let us know.
Reviews for SC 560
Average Rating: 5 (Based on 1 Review.)
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a COX-1 inhibitor.
By
Anonymous on 02/01/2018
Assay Type: Ex Vivo
Species: Rat
It is a higly lipophilic COX-1 inhibitor. It decreased tACPD-induced prostaglandin E2 in rat brain slice.
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