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Submit ReviewSCH 336
Description: Highly potent and selective CB2 inverse agonist
Chemical Name: N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for SCH 336
SCH 336 is a highly potent and selective CB2 receptor inverse agonist (Ki = 1.8 nM, EC50 = 2 nM). Displays 100-fold selectivity for CB2 receptors over CB1. Increases Forskolin stimulated cAMP accumulation in CHO cells expressing human CB2 receptors. Inhibits leukocyte migration in a murine model of delayed-type hypersensitivity and inhibits antigen-induced lung eosinophilia in a mouse allergy model.
Compound Libraries for SCH 336
SCH 336 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SCH 336
| M. Wt | 539.64 |
| Formula | C23H25NO8S3 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 447459-51-0 |
| PubChem ID | 10324989 |
| InChI Key | NXODIUKWAVUFGF-INIZCTEOSA-N |
| Smiles | CS(N[C@@H](C)C1=CC=C(S(C2=C(S(=O)(C3=CC=C(OC)C=C3)=O)C=C(OC)C=C2)(=O)=O)C=C1)(=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SCH 336
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 53.96 | 100 |
Preparing Stock Solutions for SCH 336
The following data is based on the product molecular weight 539.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.85 mL | 9.27 mL | 18.53 mL |
| 5 mM | 0.37 mL | 1.85 mL | 3.71 mL |
| 10 mM | 0.19 mL | 0.93 mL | 1.85 mL |
| 50 mM | 0.04 mL | 0.19 mL | 0.37 mL |
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Product Datasheets for SCH 336
References for SCH 336
References are publications that support the biological activity of the product.
Lunn et al (2006) A novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist blocks leukocyte recruitment in vivo. J.Pharmacol.Exp.Ther. 316 780 PMID: 16258021
If you know of a relevant reference for SCH 336, please let us know.
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Keywords: SCH 336, SCH 336 supplier, SCH336, potent, selective, cannabinoid, 2, receptor, CB2, inverse, agonists, Receptors, 5815, Tocris Bioscience
1 Citation for SCH 336
Citations are publications that use Tocris products. Selected citations for SCH 336 include:
Dos-Santos-Pereira et al (2020) Cannabidiol prevents LPS-induced microglial inflammation by inhibiting ROS/NF-κB-dependent signaling and glucose consumption. Glia 68 561 PMID: 31647138
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.