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Submit ReviewSEA 0400
Discontinued Product
6164 has been discontinued.
Description: Potent Na+/Ca2+ exchanger (NCX) inhibitor
Chemical Name: 2-[4-[(2,5-Difluorophenyl)methoxy]phenoxy]-5-ethoxybenzenamine
Purity: ≥98% (HPLC)
Biological Activity for SEA 0400
SEA 0400 is a potent Na+/Ca2+ exchanger (NCX) inhibitor. Inhibits NCX activity in rat astrocytes, microglia and cultured neurons, canine cardiac sarcolemmal vesicles and rat cardiomyocytes (IC50 values are 5 and 8.3, 33, 90 and 92 nM, respectively). Reduces infarct volumes and exhibits protective effects against myocardial ischemia in rats.
Compound Libraries for SEA 0400
SEA 0400 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SEA 0400
| M. Wt | 371.38 |
| Formula | C21H19F2NO3 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 223104-29-8 |
| PubChem ID | 644100 |
| InChI Key | YSUBLPUJDOWYDP-UHFFFAOYSA-N |
| Smiles | CCOC1=CC(N)=C(C=C1)OC2=CC=C(C=C2)OCC3=C(C=CC(F)=C3)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SEA 0400
References for SEA 0400
References are publications that support the biological activity of the product.
Takahashi et al (2003) Protective effects of SEA0400, a novel and selective inhibitor of the Na+/Ca2+ exchanger, on myocardial ischemia-reperfusion injuries. Eur.J.Pharmacol. 458 155 PMID: 12498920
Christ et al (2016) Block of Na(+)/Ca(2+) exchanger by SEA0400 in human right atrial preparations from patients in sinus rhythm and in atrial fibrillation. Eur.J.Pharmacol. 788 286 PMID: 27373849
Karashima et al (2007) Involvement of Na+-Ca2+ exchanger in cAMP-mediated relaxation in mice aorta: evaluation using transgenic mice. Br.J.Pharmacol. 150 343 PMID: 17220909
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Keywords: SEA 0400, SEA 0400 supplier, SEA0400, Inhibitors, Inhibits, NCX, Na+/Ca2+, exchanger, cardioprotectant, Exchanger, 6164, Tocris Bioscience
3 Citations for SEA 0400
Citations are publications that use Tocris products. Selected citations for SEA 0400 include:
Neubert et al (2020) NCX1 Represents an Ionic Na+ Sensing Mechanism in Macrophages. PLoS Biol 18 PMID: 32569301
Yan et al (2019) Blockade of the forward Na+ /Ca2+ exchanger suppresses the growth of glioblastoma cells through Ca2+ -mediated cell death. Br J Pharmacol 176 2691-2707 PMID: 31034096
Bradley J et al (2019) Intracellular Ca2+ Homeostasis and Nuclear Export Mediate Exit from Naive Pluripotency. Cell Stem Cell 25 210-224.e6 PMID: 31104942
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