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Submit ReviewSEN 12333
Discontinued Product
4441 has been discontinued.
Description: α7 nAChR agonist; also histamine H3 antagonist
Alternative Names: WAY 317538
Chemical Name: N-[4-(3-pyridinyl)phenyl]-4-morpholinepentanamide
Purity: ≥99% (HPLC)
Biological Activity for SEN 12333
SEN 12333 is a α7 nicotinic acetylcholine receptor (nAChR) agonist (EC50 = 1.6 μM, Ki = 260 nM at rat α7 nAChRs). Also displays functional antagonism at histamine H3 receptors (IC50 = 103 nM) and weak agonist activity at human ganglionic α3 nAChRs (IC50 = 8.5 μM). Neuroprotective in a rodent model of quisqualic acid-induced cholinergic degeneration. Brain penetrant and orally bioavailable.
Technical Data for SEN 12333
| M. Wt | 339.43 |
| Formula | C20H25N3O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 874450-44-9 |
| PubChem ID | 45484303 |
| InChI Key | XCHIZTUBUXZESJ-UHFFFAOYSA-N |
| Smiles | O=C(CCCCN3CCOCC3)NC(C=C2)=CC=C2C1=CC=CN=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SEN 12333
References for SEN 12333
References are publications that support the biological activity of the product.
Roncarati et al (2009) Procognitive and neuroprotective activity of a novel α7 nicotinic acetylcholine receptor agonist for treatment of neurodegenerative and cognitive disorders. J.Pharmacol.Exp.Ther. 329 459 PMID: 19223665
Beinat et al (2012) Consequences of linker length alteration of the α7 nicotinic acetylcholine receptor (nAChR) agonist, SEN12333. Bioorg.Med.Chem.Lett. 22 2380 PMID: 22410083
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Keywords: SEN 12333, SEN 12333 supplier, SEN12333, WAY317538, WAY, 317538, alpha7, a7, α7, nicotinic, acetylcholine, receptors, nAChR, agonists, histamine, h3, functional, antagonists, brain, penetrant, orally, bioavailable, Nicotinic, (a7), Receptors, Histamine, H3, 4441, Tocris Bioscience
Citations for SEN 12333
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Currently there are no citations for SEN 12333.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.
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