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Submit ReviewSER 601
Description: Potent, selective CB2 agonist
Alternative Names: COR 167
Chemical Name: N-(Adamant-1-yl)-6-isopropyl-4-oxo-1-pentyl-1,4-dihydroquinoline-3-carboxamide
Purity: ≥99% (HPLC)
Biological Activity for SER 601
Potent and selective CB2 receptor agonist (Ki values are 6.3 nM and 1.2 μM for CB2 and CB1 receptors respectively). Displays analgesic activity in the formalin test in mice.
Technical Data for SER 601
| M. Wt | 434.61 |
| Formula | C28H38N2O2 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 1048038-90-9 |
| PubChem ID | 25034551 |
| InChI Key | KUMKLUDNETVLDS-UHFFFAOYSA-N |
| Smiles | O=C(C4=CN(CCCCC)C5=C(C=C(C(C)C)C=C5)C4=O)NC12CC(C3)CC(CC3C2)C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for SER 601
References for SER 601
References are publications that support the biological activity of the product.
Pasquini et al (2008) Investigations on the 4-quinolone-3-carboxylic acid motif. 2. Synthesis and structure-activity relationship of potent and selective cannabinoid-2 receptor agonists endowed with analgesic activity in vivo. J.Med.Chem. 51 5075 PMID: 18680276
Contartese (2012) A novel CB2 agonist, COR167, potently protects rat brain cortical slices against OGD and reperfusion injury. Pharmacol.Res. 66 555 PMID: 23036353
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Keywords: SER 601, SER 601 supplier, Potent, selective, CB2, receptors, agonists, analgesic, cannabinoids, SER601, cb2r, COR, 167, COR167, Receptors, 3556, Tocris Bioscience
1 Citation for SER 601
Citations are publications that use Tocris products. Selected citations for SER 601 include:
Blaha et al (2016) Impaired Excitatory Neurotransmission in the Urinary Bladder from the Obese Zucker Rat: Role of Cannabinoid Receptors. PLoS One 11 e0157424 PMID: 27285468
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Cannabinoid Receptor Ligands Scientific Review
Written by Roger Pertwee, this review discusses compounds which affect the activity of the endocannabinoid system, focusing particularly on ligands that are most widely used as experimental tools and denotes compounds available from Tocris.