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Submit ReviewSGC 3027
Description: Potent and selective PRMT7 inhibitor
Chemical Name: N-(4-((((2S,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)thio)butyl)-N-((4'-chloro-[1,1'-biphenyl]-3-yl)methyl)-3-methyl-3-(2,4,5-trimethyl-3,6-dioxocyclohexa-1,4-dien-1-yl)butanamide
Purity: ≥97% (HPLC)
Biological Activity for SGC 3027
SGC 3027 is a potent and selective PRMT7 inhibitor (IC50 < 2.5 nM); pro-drug of SGC 8158. Methylates H2B (23-37). Exhibits > 40-fold selectivity over other histone methyltransferases and non-epigenetic targets. Inhibits methylation of HSP70 in C2C12 cells.
Negative control, SGC 3027N (Cat. No. 6838) also available.
Licensing Information
This probe is supplied in conjunction with the Structural Genomics Consortium. For further characterization details, please visit the SGC 3027 probe summary on the SGC website.
Technical Data for SGC 3027
| M. Wt | 787.37 |
| Formula | C41H47ClN6O6S |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 2624313-13-7 |
| PubChem ID | 137333447 |
| InChI Key | MLJVGAYSVYMPSB-MSUKGTQXSA-N |
| Smiles | ClC1=CC=C(C2=CC(CN(CCCCSC[C@H]3O[C@@H](N4C=NC5=C4N=CN=C5N)[C@H](O)[C@@H]3O)C(CC(C6=C(C)C(C(C)=C(C)C6=O)=O)(C)C)=O)=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SGC 3027
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 78.74 | 100 |
Preparing Stock Solutions for SGC 3027
The following data is based on the product molecular weight 787.37. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.27 mL | 6.35 mL | 12.7 mL |
| 5 mM | 0.25 mL | 1.27 mL | 2.54 mL |
| 10 mM | 0.13 mL | 0.64 mL | 1.27 mL |
| 50 mM | 0.03 mL | 0.13 mL | 0.25 mL |
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Product Datasheets for SGC 3027
References for SGC 3027
References are publications that support the biological activity of the product.
Szewczyk et al (2020) Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress responses. Nat.Commun. 11 2396 PMID: 32409666
If you know of a relevant reference for SGC 3027, please let us know.
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Keywords: SGC 3027, SGC 3027 supplier, SGC3027, Potent, selective, PRMT7, inhibitors, inhibits, Protein, Arginine, Methyltransferases, 6825, Tocris Bioscience
Citations for SGC 3027
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Epigenetics Scientific Review
Written by Susanne Müller-Knapp and Peter J. Brown, this review gives an overview of the development of chemical probes for epigenetic targets, as well as the impact of these tool compounds being made available to the scientific community. In addition, their biological effects are also discussed. Epigenetic compounds available from Tocris are listed.