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Submit ReviewSGX 523
Description: Selective and potent c-MET kinase inhibitor
Chemical Name: 6-[[6-(1-Methyl-1H-pyrazol-4-yl)-1,2,4-triazolo[4,3-b]pyridazin-3-yl]thio]quinoline
Purity: ≥99% (HPLC)
Biological Activity for SGX 523
SGX 523 is a potent and selective c-MET kinase inhibitor (IC50 = 4nM). Exhibits minimal inhibition against a panel of 213 other protein kinases (at 1 μM). Suppresses growth of tumor xenografts derived from human glioblastoma, lung and gastric cancer cells.
External Portal Information for SGX 523
Chemicalprobes.org is a portal that offers independent guidance on the selection and/or application of small molecules for research. The use of SGX 523 is reviewed on the chemical probes website.
Compound Libraries for SGX 523
SGX 523 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for SGX 523
| M. Wt | 359.41 |
| Formula | C18H13N7S |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1022150-57-7 |
| PubChem ID | 24779724 |
| InChI Key | BCZUAADEACICHN-UHFFFAOYSA-N |
| Smiles | CN1N=CC(C(C=C2)=NN3C2=NN=C3SC4=CC5=CC=CN=C5C=C4)=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for SGX 523
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 7.19 | 20 |
Preparing Stock Solutions for SGX 523
The following data is based on the product molecular weight 359.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 13.91 mL | 69.56 mL | 139.12 mL |
| 1 mM | 2.78 mL | 13.91 mL | 27.82 mL |
| 2 mM | 1.39 mL | 6.96 mL | 13.91 mL |
| 10 mM | 0.28 mL | 1.39 mL | 2.78 mL |
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Product Datasheets for SGX 523
References for SGX 523
References are publications that support the biological activity of the product.
Buchanan et al (2009) SGX523 is an exquisitely selective, ATP-competitive inhibitor of the MET receptor tyrosine kinase with antitumor activity in vivo. Mol.Cancer.Ther. 8 3181 PMID: 19934279
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Keywords: SGX 523, SGX 523 supplier, SGX523, Selective, potent, c-MET, kinase, inhibitors, inhibits, MET, Receptors, 5356, Tocris Bioscience
2 Citations for SGX 523
Citations are publications that use Tocris products. Selected citations for SGX 523 include:
Ortega et al (2017) Adhesion to the host cell surface is sufficient to mediate Listeria monocytogenes entry into epithelial cells. Mol Biol Cell 28 2945 PMID: 28877987
Bastounis et al (2018) Matrix stiffness modulates infection of endothelial cells by Listeria monocytogenes via expression of cell surface vimentin. Mol Biol Cell 29 1571 PMID: 29718765
Do you know of a great paper that uses SGX 523 from Tocris? Please let us know.
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